如何降低分子分类子宫内膜癌的 "无特异性分子特征 "异质性?L1细胞粘附分子的预后意义。

IF 1.6 4区 医学 Q3 OBSTETRICS & GYNECOLOGY International Journal of Gynecological Pathology Pub Date : 2024-07-29 DOI:10.1097/PGP.0000000000001057
Cem Yagmur Ozdemir, Dagistan Tolga Arioz, Mine Kanat Pektaş, Cigdem Ozdemir, Nayif Cicekli, Filiz Bilir, Riza Dur, Ecenur Goztepe
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引用次数: 0

摘要

本研究旨在探讨 L1 细胞粘附分子(L1CAM)在分子分类中被描述为无特异性分子特征(NSMP)的子宫内膜癌预后评估中的作用。这是一项回顾性研究,研究对象是2008年1月至2022年1月期间在研究中心确诊为子宫内膜癌并接受手术的150名患者。在评估 L1CAM 免疫组化染色时,根据肿瘤细胞的阳性率进行评分。因此,0分=0%,1分=1%至10%,2分=>10%至50%,3分=>50%。如果肿瘤细胞中的染色≥10%(2分和3分),则被视为阳性。与 L1CAM 阴性患者相比,L1CAM 阳性患者淋巴管间隙侵犯和淋巴结转移的频率明显更高(P = 0.013 和 P = 0.007)。L1CAM的表达与突变p53密切相关(P = 0.003)。L1CAM阳性患者的复发率明显较高(P = 0.001),总生存期和无进展生存期明显较低(P = 0.001)。79名患者(52.7%)被归入NSMP组。其中约84.8%(n = 67)为L1CAM阴性,15.2%(n = 12)为L1CAM阳性。L1CAM阳性的NSMP患者复发率明显更高(P = 0.001),总生存期和无进展生存期明显更低(分别为P = 0.002和P = 0.001)。这项研究表明,L1CAM表达状态可能会增加子宫内膜癌的预后信息,尤其是在NSMP亚组中。考虑到L1CAM在预后方面的重要性,将其作为一种标记物可能会大大有助于减少预后异质性,尤其是在NSMP亚组中。
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How Can "No Specific Molecular Profile" Heterogeneity be Reduced in Molecularly Classified Endometrial Cancer?: Prognostic Significance of L1 Cell Adhesion Molecule.

This study aims to investigate the role of L1 cell adhesion molecule (L1CAM) in the prognostic assessment of endometrial cancers that have been depicted as having no specific molecular profile (NSMP) in molecular classification. This is a retrospective review of 150 patients who received the diagnosis of endometrial cancer and underwent surgery at the study center between January 2008 and January 2022. When evaluating L1CAM immunohistochemical staining, scoring was done according to the percentage of positivity in tumor cells. Accordingly, score 0 = 0%, score 1=1% to 10%, score 2 = >10% to 50% and score 3 = >50%. If the staining in tumor cells was ≥10% (scores 2 and 3), it was considered positive. The patients with L1CAM positivity had significantly more frequent lymphovascular space invasion and lymph node metastasis than patients with L1CAM negativity (P = 0.013 and P = 0.007). L1CAM expression was strongly associated with mutant p53 (P = 0.003). Recurrence was significantly higher (P = 0.001) and overall survival and progression-free survival were significantly lower in patients with L1CAM positivity (P = 0.001 for both). Seventy-nine patients (52.7%) were put into NSMP group. About 84.8% of them (n = 67) were L1CAM negative and 15.2% of them (n = 12) were L1CAM-positive. Recurrence was significantly higher (P = 0.001) and overall survival and progression-free survival were significantly lower in patients with NSMP who were positive for L1CAM (P = 0.002 and P = 0.001, respectively). This study demonstrates that L1CAM expression status may add prognostic information to endometrial cancer, particularly in the NSMP subgroup. Considering the prognostic importance of L1CAM, its use as a marker may make significant contributions to reducing prognostic heterogeneity, especially in the NSMP subgroup.

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来源期刊
CiteScore
3.90
自引率
12.50%
发文量
154
审稿时长
6-12 weeks
期刊介绍: International Journal of Gynecological Pathology is the official journal of the International Society of Gynecological Pathologists (ISGyP), and provides complete and timely coverage of advances in the understanding and management of gynecological disease. Emphasis is placed on investigations in the field of anatomic pathology. Articles devoted to experimental or animal pathology clearly relevant to an understanding of human disease are published, as are pathological and clinicopathological studies and individual case reports that offer new insights.
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