澳大利亚向囊性纤维化患者发放精神药物的普遍程度:2013-2022 年

IF 3.5 2区 医学 Q2 PSYCHIATRY Journal of Psychosomatic Research Pub Date : 2024-08-08 DOI:10.1016/j.jpsychores.2024.111877
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引用次数: 0

摘要

目标囊性纤维化患者(PwCF)罹患精神疾病的风险增加。有关囊性纤维化患者使用精神药物的证据很少。本研究旨在估算 2013 年至 2022 年期间澳大利亚囊肿性纤维化患者的抗抑郁药、抗焦虑药、抗精神病药、精神刺激药和催眠药/镇静药的配药率。结果206/478(41.3%)名贫困家庭接受了精神药物治疗。抗抑郁药和抗焦虑药的配药率在成年女性中最高,从 2015 年开始增加 50%,到 2021 年达到峰值(抗抑郁药 36.8%;抗焦虑药 12.3%)。青少年男性的精神兴奋剂使用率最高,在研究期间增长了三倍多,从 3.6% 增长到 13.2%。抗精神病药物的使用率低于其他类药物,其中成年女性的使用率最高(2015 年为 3.1%,2022 年为 5.8%)。除男性儿童外,催眠/镇静药物在所有群体中的使用率始终较低或有所下降,男性儿童的使用率从 2015 年的 0.6% 上升到 2022 年的 2.8%。由于CF合并症的复杂性以及潜在的药物影响和相互作用,这种情况值得关注。未来的研究应调查造成儿童和成人精神药物使用差异的原因,以制定有针对性的指导原则并优化治疗效果。
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Prevalence of psychotropic medication dispensing to people living with cystic fibrosis in Australia: 2013–2022

Objective

People living with cystic fibrosis (PwCF) are at increased risk of mental health conditions. There is little evidence addressing psychotropic medication use in PwCF. This study aimed to estimate the dispensing prevalence of antidepressant, anxiolytic, antipsychotic, psychostimulant, and hypnotic/sedative medication in PwCF in Australia between 2013 and 2022.

Method

A 10% random sample of Australian Pharmaceutical Benefits Scheme data was used to identify PwCF and their medications between 2013 and 2022. Annual prevalence of psychotropic medication dispensing was estimated using a 3-year rolling average, stratified by sex, age, and medication class.

Results

Psychotropic medications were dispensed to 206/478 (41.3%) PwCF. Antidepressant and anxiolytic dispensing prevalence was highest in adult females, increasing from 201 5 by 50% to their peak in 2021 (antidepressants 36.8%; anxiolytics 12.3%). Psychostimulant prevalence was highest in adolescent males and increased over three-fold during the study period from 3.6% to 13.2%. The prevalence of antipsychotic medication was lower than other classes with adult females having the highest prevalence (3.1% and 5.8% in 201 5 and 2022 respectively). Hypnotic/sedative medications remained consistently low or decreased in all groups except male children, where it increased from 0.6% to 2.8% from 201 5 to 2022.

Conclusion

Psychotropic medication use is higher among Australian PwCF compared to the general population, with varying prevalence across age and sex groups. This is of interest due to complexities with CF comorbidities and potential medication influences and interactions. Future studies should investigate the reasons for psychotropic use disparities within PwCF with the aim to establish targeted guidelines and optimize outcomes.

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来源期刊
Journal of Psychosomatic Research
Journal of Psychosomatic Research 医学-精神病学
CiteScore
7.40
自引率
6.40%
发文量
314
审稿时长
6.2 weeks
期刊介绍: The Journal of Psychosomatic Research is a multidisciplinary research journal covering all aspects of the relationships between psychology and medicine. The scope is broad and ranges from basic human biological and psychological research to evaluations of treatment and services. Papers will normally be concerned with illness or patients rather than studies of healthy populations. Studies concerning special populations, such as the elderly and children and adolescents, are welcome. In addition to peer-reviewed original papers, the journal publishes editorials, reviews, and other papers related to the journal''s aims.
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