各种水果提取物对血管紧张素 I 转换酶 (ACE) 和 Kallikrein (KLK) 活性的影响。

IF 3.1 2区 农林科学 Q2 CHEMISTRY, APPLIED Plant Foods for Human Nutrition Pub Date : 2024-08-24 DOI:10.1007/s11130-024-01223-5
Shuang Gu, Qiaojia Ling, Guifeng Bao, Lin Xie, Yongqing Shi, Xiangyang Wang
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引用次数: 0

摘要

高血压是心血管疾病的主要危险因素之一,在全球范围内造成广泛的发病率和死亡率。本研究旨在通过三种不同的提取方法,从 22 种水果中筛选出具有较高血管紧张素 I 转换酶(ACE)抑制活性和 Kallikrein(KLK)促进活性的水果。结果表明,新鲜猕猴桃的水提取物能显著抑制 ACE 活性(47.71%),而 KLK 活性也受到抑制(4.56%)。这表明猕猴桃中存在的抑制 ACE 活性的物质可能是多酚等小分子物质。葡萄乙醇提取物中的非极性物质对 ACE 活性有明显的抑制作用。红提的酶水解物对 KLK 活性有明显的促进作用,而其乙醇提取物则对 KLK 活性有明显的抑制作用。这一结果表明,降血压和升血压的成分一般存在于同一种水果中,前者多为水溶性物质,后者多为醇溶性物质。如果能从食用水果中分离出某些或个别成分,它们可能会对人体血压产生重大影响。
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Effect of Various Fruit Extracts on Angiotensin I-Converting Enzyme (ACE) and Kallikrein (KLK) Activities.

Hypertension is one of the main risk factors for cardiovascular disease and causes widespread morbidity and mortality worldwide. The aim of this work was to screen the fruit with high angiotensin I-converting enzyme (ACE) inhibitory activity and kallikrein (KLK) promotion activity by three different extraction methods from 22 kinds of fruits. Results showed that the aqueous extracts of fresh kiwifruit significantly inhibited ACE activity (47.71%), whereas the KLK activity was also inhibited (4.56%). This indicated that the substances inhibiting ACE activity existed in kiwifruit might be small molecular substances such as polyphenols. The nonpolar substance existed in the ethanol extracts of grape inhibited ACE activity significantly. The enzymatic hydrolysates of red grape significantly promoted KLK activity, whereas its ethanol extracts significantly inhibited KLK activity. This results suggested that the components that lower blood pressure and raise blood pressure are generally presented in the same fruit, the former are mostly water-soluble substances, while the latter are generally alcohol-soluble substances. If certain or individual components can be isolated from edible fruits, they may significantly affect blood pressure in humans.

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来源期刊
Plant Foods for Human Nutrition
Plant Foods for Human Nutrition 工程技术-食品科技
CiteScore
6.80
自引率
7.50%
发文量
89
审稿时长
12-24 weeks
期刊介绍: Plant Foods for Human Nutrition (previously Qualitas Plantarum) is an international journal that publishes reports of original research and critical reviews concerned with the improvement and evaluation of the nutritional quality of plant foods for humans, as they are influenced by: - Biotechnology (all fields, including molecular biology and genetic engineering) - Food science and technology - Functional, nutraceutical or pharma foods - Other nutrients and non-nutrients inherent in plant foods
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