预防性氨甲环酸对灰狗术后出血发生率的影响。

IF 2.3 2区 农林科学 Q1 VETERINARY SCIENCES Veterinary journal Pub Date : 2024-08-22 DOI:10.1016/j.tvjl.2024.106226
O.P. Gilman , K. Borgeat , H.E. Wilson
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引用次数: 0

摘要

为了研究在对接受手术的灰狗实施氨甲环酸(TXA)预防性用药的标准化方案后,灰狗术后出血的发生率是否会降低,一家私人转诊和第一意见医院集团开展了一项回顾性临床研究。研究人员回顾性检查了客户饲养的灰猎犬接受择期手术或牙科拔牙手术的病历,并记录了58例符合条件的手术,以及随后的出血报告和是否遵循了氨甲环酸治疗方案。在这些灰狗中,使用 TXA 与降低术后出血发生率无关。在未使用 TXA 的组别中,7/37(18.9%)的病例报告了术后出血,而在使用预防性 TXA 的组别中,11/21(52.4%)的病例报告了术后出血,明显高于未使用 TXA 的组别。有趣的是,在我们的研究对象中,预防性使用 TXA 与术后出血减少无关,而是与出血发生率升高有关。我们认为,我们的数据集可能存在缺陷,因此应进行前瞻性随机对照试验,进一步研究 TXA 作为抗纤维蛋白溶解剂对灰猎犬的疗效。
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The effect of prophylactic tranexamic acid on the incidence of postoperative hemorrhage in greyhounds

To investigate whether the incidence of postoperative hemorrhage in greyhounds was reduced when a standardized protocol for prophylactic tranexamic acid (TXA) administration to greyhounds undergoing surgery was followed, a retrospective clinical study at a private referral and first opinion hospital group was performed. Patient records of client-owned greyhounds undergoing elective surgery or dental procedures involving extractions were examined retrospectively, and 58 incidents of surgery considered eligible were documented, along with any subsequent reports of hemorrhage and whether the TXA protocol was followed.

The use of TXA was not associated with a reduction in the incidence of postoperative hemorrhage in this population of greyhounds. In the group that did not receive TXA, post-operative hemorrhage was reported in 7/37 (18.9 %) cases and in the prophylactic TXA group, post-operative hemorrhage was reported in 11/21 (52.4 %) cases, a significantly higher number than in the group that did not receive TXA. Interestingly, in our population, prophylactic administration of TXA was not associated with a reduction in post-operative hemorrhage, but with a higher incidence of hemorrhage. We belief that descrepencies in our dataset may explain these findings, and a prospective randomized-controlled trial should be performed to further investigate the efficacy of TXA as an antifibrinolytic agent in greyhounds.

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来源期刊
Veterinary journal
Veterinary journal 农林科学-兽医学
CiteScore
4.10
自引率
4.50%
发文量
79
审稿时长
40 days
期刊介绍: The Veterinary Journal (established 1875) publishes worldwide contributions on all aspects of veterinary science and its related subjects. It provides regular book reviews and a short communications section. The journal regularly commissions topical reviews and commentaries on features of major importance. Research areas include infectious diseases, applied biochemistry, parasitology, endocrinology, microbiology, immunology, pathology, pharmacology, physiology, molecular biology, immunogenetics, surgery, ophthalmology, dermatology and oncology.
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