The compliance of sepsis resuscitation care bundle in patients diagnosed with septic shock or sepsis to the International Surviving Sepsis Campaign among patients admitted to a tertiary and teaching hospital, Ethiopia: A 1-year prospective observational study

Background

High rates of morbidity and mortality would be seen in patients suffering from sepsis and/or septic shock. It has been hypothesised that the Surviving Sepsis Campaign will reduce the morbidity and mortality of individuals who are diagnosed with septic shock and/or sepsis. Improving the surviving sepsis campaign's execution is necessary to reduce these deleterious occurrences. There is currently a lack of local data regarding the management in accordance with the guidelines in the Surviving Sepsis Campaign.Therefore, this study aimed to assess the compliance rate of sepsis resuscitation care bundle in patients diagnosed with septic shock and/or sepsis to the International Surviving Sepsis Campaign among patients admitted to a tertiary and teaching hospital, Ethiopia.

Methods

Hospital based, prospective observational study was conducted from January 1/2023 to December 31, 2023. Consecutive sampling technique was employed to select study participants for a period of one year and the smaple size was found to be 88 participants. A prepared checklist with standards taken from the International Surviving Sepsis Campaign was used to collect the data. Data were collected through direct-observation, interviewing the responsible physician who made the sepsis and/or septic shock diagnosis, and reviewing patient charts. Data were entered and analysed with statistical package for social sciences (SPSS) version-25.

Results

In treating patients diagnosed with septic shock and/or sepsis, the total compliance rate with the International Surviving Sepsis Campaign's (ISSC) sepsis resuscitation care bundle was 38 %. In the initial one-hour care bundle, 100 % of patients received the RECOMMENDED initial fluid resuscitation, 64 (72.7 %) of patients received broad spectrum antibiotics, 12 (14 %) of patients had blood culture before antibiotics.

Conclusions

This study concluded that sepsis resuscitation care bundle practice was subpar. Therefore, we recommend that educational training, increased awareness, and sharing the current and existing evidences are an important measures to improve the utility of the recommendations of the International Surviving Sepsis Campaign's (ISSC). After the sepsis treatment bundle has been fully implemented, a re-evaluation will take place in the summer of 2025.