糖基转移酶介导的小分子糖化研究进展。

IF 2.6 4区 生物学 Q3 BIOTECHNOLOGY & APPLIED MICROBIOLOGY 3 Biotech Pub Date : 2024-09-01 Epub Date: 2024-08-23 DOI:10.1007/s13205-024-04044-0
Nguyen Huy Thuan, Quach Thi Thu Huong, Bui Dinh Lam, Ho Thanh Tam, Pham The Thu, Nguyen Xuan Canh, Vinay Bharadwaj Tatipamula
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摘要

目前,已经合成了许多苷类化合物,并将其用于临床应用、中性药物、化妆品和食品加工。从结构上看,苷是由一个或多个糖分子(即所谓的糖酮)连接的苷元组成。研究发现,苷的生物化学或生物制药特性主要取决于其糖部分,因此,糖酮的交替也会产生新的结构和特性。使用传统的苷类生产方法,如直接从植物、动物或微生物中提取和纯化,非常具有挑战性(费力、费时、费技术、价格高、产量低等)。另外,使用酶法进行苷类化合物的生物合成已成为一种极具前景的工具。特别是利用从生物资源(植物、真菌、微生物等)中挖掘出的糖基转移酶(GT)的杂乱催化活性,可以获得结构多样的苷类化合物。此外,糖基转移酶对各种苷元和糖醛酸的催化杂合性的探索也非常有趣,并在新型苷的生产中发挥了关键作用。本综述介绍了糖基转移酶介导的小分子(类黄酮、类固醇、萜类化合物等)糖苷化的最新进展。大部分参考文献收集自 2014 年至 2023 年。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

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Advances in glycosyltransferase-mediated glycodiversification of small molecules.

Currently, numerous glycosides have been synthesized and used in clinical applications, neutraceuticals, cosmetics, and food processing. Structurally, a glycoside is composed of aglycone attaching to one or several sugar moieties so-called glycone. It is found that biochemical or biopharmaceutical properties of glycoside are mainly determined by its sugar part and thereby alternation of this glycone resulting in novel structure and characteristics as well. The use of traditional production methods of glycosides such as direct extraction and purification from plants, animals, or microorganisms is very challenging (laborious, time-consuming, technique, high price, low yield, etc.). Alternatively, the use of enzymatic methods for the biosynthesis of glycosides has become a highly promising tool. Particularly, the diverse structure of glycosides can be obtained using the promiscuous catalytic activity of glycosyltransferases (GT) mined from bioresources (plants, fungi, microorganisms, etc.). In addition, the exploration of GT catalytic promiscuity toward diverse aglycones, and glycones has indeed been interesting and played a key role in the production of novel glycosides. This review described the recent advances in glycosyltransferase-mediated glycodiversification of small molecules (flavonoids, steroids, terpenoids, etc.). Mostly, references were collected from 2014 to 2023.

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来源期刊
3 Biotech
3 Biotech Agricultural and Biological Sciences-Agricultural and Biological Sciences (miscellaneous)
CiteScore
6.00
自引率
0.00%
发文量
314
期刊介绍: 3 Biotech publishes the results of the latest research related to the study and application of biotechnology to: - Medicine and Biomedical Sciences - Agriculture - The Environment The focus on these three technology sectors recognizes that complete Biotechnology applications often require a combination of techniques. 3 Biotech not only presents the latest developments in biotechnology but also addresses the problems and benefits of integrating a variety of techniques for a particular application. 3 Biotech will appeal to scientists and engineers in both academia and industry focused on the safe and efficient application of Biotechnology to Medicine, Agriculture and the Environment.
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