Napasiri Putthanbut, Jea Young Lee, Cesario V Borlongan
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引用次数: 0
摘要
细胞外囊泡(EVs)对细胞间的通讯至关重要,在各种生理和病理过程中传输蛋白质、脂质和核酸。它们在免疫调节和组织再生中发挥着至关重要的作用,但也与炎症和退行性疾病等致病因素有关。EVs 的种群和载体各不相同,目前有许多亚群正在接受研究。与细胞疗法相比,EV疗法在刺激组织修复和作为药物输送载体方面前景广阔,具有易于工程化和肿瘤发生风险最小等优势。然而,挑战依然存在,包括命名不一致、特征描述复杂以及大规模生产协议开发不足。这篇综述重点介绍了 EVs 异质性的最新进展和意义,强调需要更好地了解 EVs 在疾病病理中的作用,以开发适合神经系统疾病临床应用的 EV 疗法。
Extracellular vesicle therapy in neurological disorders.
Extracellular vesicles (EVs) are vital for cell-to-cell communication, transferring proteins, lipids, and nucleic acids in various physiological and pathological processes. They play crucial roles in immune modulation and tissue regeneration but are also involved in pathogenic conditions like inflammation and degenerative disorders. EVs have heterogeneous populations and cargo, with numerous subpopulations currently under investigations. EV therapy shows promise in stimulating tissue repair and serving as a drug delivery vehicle, offering advantages over cell therapy, such as ease of engineering and minimal risk of tumorigenesis. However, challenges remain, including inconsistent nomenclature, complex characterization, and underdeveloped large-scale production protocols. This review highlights the recent advances and significance of EVs heterogeneity, emphasizing the need for a better understanding of their roles in disease pathologies to develop tailored EV therapies for clinical applications in neurological disorders.
期刊介绍:
The Journal of Biomedical Science is an open access, peer-reviewed journal that focuses on fundamental and molecular aspects of basic medical sciences. It emphasizes molecular studies of biomedical problems and mechanisms. The National Science and Technology Council (NSTC), Taiwan supports the journal and covers the publication costs for accepted articles. The journal aims to provide an international platform for interdisciplinary discussions and contribute to the advancement of medicine. It benefits both readers and authors by accelerating the dissemination of research information and providing maximum access to scholarly communication. All articles published in the Journal of Biomedical Science are included in various databases such as Biological Abstracts, BIOSIS, CABI, CAS, Citebase, Current contents, DOAJ, Embase, EmBiology, and Global Health, among others.