使用基于双能 CT 的胶原图评估胸椎椎间盘退变。

IF 3.7 Q1 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING European Radiology Experimental Pub Date : 2024-08-26 DOI:10.1186/s41747-024-00500-x
Simon Bernatz, Alexander Tom Hoppe, Leon David Gruenewald, Vitali Koch, Simon S Martin, Lara Engelskirchen, Ivana Radic, Giuseppe Bucolo, Jennifer Gotta, Philipp Reschke, Renate M Hammerstingl, Jan-Erik Scholtz, Tatjana Gruber-Rouh, Katrin Eichler, Thomas J Vogl, Christian Booz, Ibrahim Yel, Scherwin Mahmoudi
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引用次数: 0

摘要

背景:我们评估了基于双能计算机断层扫描(DECT)的胶原图在评估胸椎椎间盘退变中的作用:我们对在2019年7月至2022年10月的两周内接受了胸椎双能计算机断层扫描(DECT)和磁共振成像(MRI)的患者进行了回顾性分析。胸椎椎间盘退变由三位盲放射科医生分为三个 Pfirrmann 类别:无/轻度(1-2 级)、中度(3-4 级)和重度(5 级)。DECT 性能以核磁共振成像作为参考标准。读片者之间的可靠性采用类内相关系数(ICC)进行评估。采用五点李克特量表评估诊断信心和图像质量:共对 51 名患者的 612 个椎间盘进行了评估,患者年龄为 68 ± 16 岁(平均 ± 标准差),其中男性 28 人,女性 23 人。磁共振成像显示,135 个椎间盘无/轻度退变(22.1%),470 个椎间盘中度退变(76.8%),7 个椎间盘严重退变(1.1%)。DECT胶原图对胸椎间盘退变的总体准确率为1,483/1,838(80.8%)。检测无/轻度退变的总体召回率(灵敏度)为 331/405(81.7%),检测中度退变的召回率(灵敏度)为 1,134/1,410 (80.4%),检测严重退变的召回率(灵敏度)为 18/21 (85.7%)。相互之间的一致性良好(ICC = 0.89)。对基于 DECT 的胶原图的评估显示,诊断可信度高(中位数为 4;四分位数间距为 3-4),图像质量好(中位数为 4;四分位数间距为 4-4):结论:通过观察胸椎椎间盘胶原蛋白含量的差异,DECT显示椎间盘退变的总体准确率为81%:利用基于 DECT 的胶原图来区分不同阶段的胸椎椎间盘退变,对于早期发现椎间盘相关疾病具有临床意义。这种方法在核磁共振成像禁忌症时可能特别有益:以核磁共振成像为参考标准,使用 DECT 对 51 名患者的 612 个椎间盘进行了回顾性评估。通过基于 DECT 的胶原图,胸椎椎间盘退变评估的总体准确率达到了 81%,且检查者之间具有良好的一致性(ICC = 0.89)。在有核磁共振成像禁忌症的情况下,基于DECT的胶原图是一种很好的替代方法。
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Assessment of thoracic disc degeneration using dual-energy CT-based collagen maps.

Background: We evaluated the role of dual-energy computed tomography (DECT)-based collagen maps in assessing thoracic disc degeneration.

Methods: We performed a retrospective analysis of patients who underwent DECT and magnetic resonance imaging (MRI) of the thoracic spine within a 2-week period from July 2019 to October 2022. Thoracic disc degeneration was classified by three blinded radiologists into three Pfirrmann categories: no/mild (grade 1-2), moderate (grade 3-4), and severe (grade 5). The DECT performance was determined using MRI as a reference standard. Interreader reliability was assessed using intraclass correlation coefficient (ICC). Five-point Likert scales were used to assess diagnostic confidence and image quality.

Results: In total, 612 intervertebral discs across 51 patients aged 68 ± 16 years (mean ± standard deviation), 28 males and 23 females, were assessed. MRI revealed 135 no/mildly degenerated discs (22.1%), 470 moderately degenerated discs (76.8%), and 7 severely degenerated discs (1.1%). DECT collagen maps achieved an overall accuracy of 1,483/1,838 (80.8%) for thoracic disc degeneration. Overall recall (sensitivity) was 331/405 (81.7%) for detecting no/mild degeneration, 1,134/1,410 (80.4%) for moderate degeneration, and 18/21 (85.7%) for severe degeneration. Interrater agreement was good (ICC = 0.89). Assessment of DECT-based collagen maps demonstrated high diagnostic confidence (median 4; interquartile range 3-4) and good image quality (median 4; interquartile range 4-4).

Conclusion: DECT showed an overall 81% accuracy for disc degeneration by visualizing differences in the collagen content of thoracic discs.

Relevance statement: Utilizing DECT-based collagen maps to distinguish various stages of thoracic disc degeneration could be clinically relevant for early detection of disc-related conditions. This approach may be particularly beneficial when MRI is contraindicated.

Key points: A total of 612 intervertebral discs across 51 patients were retrospectively assessed with DECT, using MRI as a reference standard. DECT-based collagen maps allowed thoracic disc degeneration assessment achieving an overall 81% accuracy with good interrater agreement (ICC = 0.89). DECT-based collagen maps could be a good alternative in the case of contraindications to MRI.

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来源期刊
European Radiology Experimental
European Radiology Experimental Medicine-Radiology, Nuclear Medicine and Imaging
CiteScore
6.70
自引率
2.60%
发文量
56
审稿时长
18 weeks
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