{"title":"锶涂层钛植入物能否增强骨质疏松动物模型的骨结合?系统综述与荟萃分析。","authors":"Osama Sayed, Mohamed Mahmoud Abdalla, Ayman Elsayed, Yehia El-Mahallawy, Haytham Al-Mahalawy","doi":"10.1038/s41405-024-00220-9","DOIUrl":null,"url":null,"abstract":"<p><strong>Purpose: </strong>The aim of this study was to systematically review the literature to address the effect of strontium modified titanium implants on the osseointegration in the presence of osteoporotic conditions through animal models.</p><p><strong>Materials and methods: </strong>The databases (PubMed, Scopus, Web of Science, and EBSCO) were searched electronically, and manual searches were performed till December 2022 to identify preclinical studies on the osseointegration of strontium coated titanium implants in animals with induced osteoporotic conditions. The primary outcomes were the bone-implant contact percentage (BIC%), bone area (BA) from the histomorphometric analysis, and the osseointegration parameters from biomechanical tests; the secondary outcomes were the osseointegration parameters from the micro computed tomography.</p><p><strong>Results: </strong>Nineteen articles were included for the quantitative analysis on basis of the inclusion criteria. The results revealed that Sr-modified implants showed a significant 19.05% increase in BIC, and 15.01% increase in BA. The results of biomechanical tests indicated a significant effect in favor of Sr-coated implants. Furthermore, Results of the secondary outcomes supported the significant advantages of Sr-coated implants over the un-coated implants. The overall, systematic analysis of implants osteointegration parameters proved a significant increase in favor of Sr-coated titanium implants (P < 0.01).</p><p><strong>Conclusion: </strong>The present results provide evidence that strontium-coated titanium implants enhanced the osseointegration in animal models under osteoporotic condition as this surface modification techniques have improved the mechanical and biological properties of the titanium implants.</p>","PeriodicalId":36997,"journal":{"name":"BDJ Open","volume":null,"pages":null},"PeriodicalIF":2.5000,"publicationDate":"2024-08-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11344846/pdf/","citationCount":"0","resultStr":"{\"title\":\"Does strontium coated titanium implants enhance the osseointegration in animal models under osteoporotic condition? 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The primary outcomes were the bone-implant contact percentage (BIC%), bone area (BA) from the histomorphometric analysis, and the osseointegration parameters from biomechanical tests; the secondary outcomes were the osseointegration parameters from the micro computed tomography.</p><p><strong>Results: </strong>Nineteen articles were included for the quantitative analysis on basis of the inclusion criteria. The results revealed that Sr-modified implants showed a significant 19.05% increase in BIC, and 15.01% increase in BA. The results of biomechanical tests indicated a significant effect in favor of Sr-coated implants. Furthermore, Results of the secondary outcomes supported the significant advantages of Sr-coated implants over the un-coated implants. The overall, systematic analysis of implants osteointegration parameters proved a significant increase in favor of Sr-coated titanium implants (P < 0.01).</p><p><strong>Conclusion: </strong>The present results provide evidence that strontium-coated titanium implants enhanced the osseointegration in animal models under osteoporotic condition as this surface modification techniques have improved the mechanical and biological properties of the titanium implants.</p>\",\"PeriodicalId\":36997,\"journal\":{\"name\":\"BDJ Open\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":2.5000,\"publicationDate\":\"2024-08-24\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11344846/pdf/\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"BDJ Open\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.1038/s41405-024-00220-9\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q2\",\"JCRName\":\"DENTISTRY, ORAL SURGERY & MEDICINE\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"BDJ Open","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1038/s41405-024-00220-9","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"DENTISTRY, ORAL SURGERY & MEDICINE","Score":null,"Total":0}
引用次数: 0
摘要
目的:本研究旨在通过动物模型系统地回顾文献,探讨锶修饰的钛植入物在骨质疏松情况下对骨结合的影响:对数据库(PubMed、Scopus、Web of Science 和 EBSCO)进行了电子检索,并在 2022 年 12 月之前进行了人工检索,以确定关于锶涂层钛植入物在诱导骨质疏松情况下的骨结合的临床前研究。主要研究结果为组织形态学分析得出的骨-植入体接触百分比(BIC%)、骨面积(BA)以及生物力学测试得出的骨结合参数;次要研究结果为显微计算机断层扫描得出的骨结合参数:根据纳入标准,19 篇文章被纳入定量分析。结果显示,锶改性种植体的BIC显著增加了19.05%,BA增加了15.01%。生物力学测试结果表明,锶涂层种植体的效果显著。此外,次要结果表明,与未涂层的种植体相比,有 Sr 涂层的种植体具有明显优势。对植入物骨整合参数的整体系统分析证明,Sr 涂层钛植入物的骨整合参数明显增加(P 结论:Sr 涂层钛植入物的骨整合参数明显增加:本研究结果证明,锶涂层钛植入物增强了骨质疏松动物模型的骨结合,因为这种表面改性技术改善了钛植入物的机械和生物特性。
Does strontium coated titanium implants enhance the osseointegration in animal models under osteoporotic condition? A systematic review and meta-analysis.
Purpose: The aim of this study was to systematically review the literature to address the effect of strontium modified titanium implants on the osseointegration in the presence of osteoporotic conditions through animal models.
Materials and methods: The databases (PubMed, Scopus, Web of Science, and EBSCO) were searched electronically, and manual searches were performed till December 2022 to identify preclinical studies on the osseointegration of strontium coated titanium implants in animals with induced osteoporotic conditions. The primary outcomes were the bone-implant contact percentage (BIC%), bone area (BA) from the histomorphometric analysis, and the osseointegration parameters from biomechanical tests; the secondary outcomes were the osseointegration parameters from the micro computed tomography.
Results: Nineteen articles were included for the quantitative analysis on basis of the inclusion criteria. The results revealed that Sr-modified implants showed a significant 19.05% increase in BIC, and 15.01% increase in BA. The results of biomechanical tests indicated a significant effect in favor of Sr-coated implants. Furthermore, Results of the secondary outcomes supported the significant advantages of Sr-coated implants over the un-coated implants. The overall, systematic analysis of implants osteointegration parameters proved a significant increase in favor of Sr-coated titanium implants (P < 0.01).
Conclusion: The present results provide evidence that strontium-coated titanium implants enhanced the osseointegration in animal models under osteoporotic condition as this surface modification techniques have improved the mechanical and biological properties of the titanium implants.