酸中毒和缺血性脑损伤。

B K Siesjö
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引用次数: 361

摘要

酸中毒是导致缺血性脑损伤的发病事件的重要组成部分,目前已被广泛接受。这篇文章的目的是回顾这一概念的演变,描述组织酸中毒产生和导致脑损伤增强的条件,并探讨所涉及的细胞和分子机制。
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Acidosis and ischemic brain damage.

It is now widely accepted that acidosis is an important component of the pathogenetic events that lead to ischemic brain damage. The objective with this article is to recall the evolution of the concept, to describe the conditions under which tissue acidosis arises and causes enhanced brain damage, and to probe into the cellular and molecular mechanisms involved.

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The mechanism of ischemia-induced brain cell injury. The membrane theory. Peroxidative damage to cell membranes following cerebral ischemia. A cause of ischemic brain injury? Phosphoinositide turnover and calcium ion mobilization in receptor activation. Polyamines in cerebral ischemia. Reduction of neural damage in irreversible cerebral ischemia by calcium antagonists.
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