Lotte Veddum , Vibeke Bliksted , Yuan Zhou , Anna Krogh Andreassen , Christina Bruun Knudsen , Aja Neergaard Greve , Nanna Lawaetz Steffensen , Merete Birk , Nicoline Hemager , Julie Marie Brandt , Maja Gregersen , Line Korsgaard Johnsen , Kit Melissa Larsen , William Frans Christiaan Baaré , Kathrine Skak Madsen , Hartwig Roman Siebner , Kerstin Jessica Plessen , Anne Amalie Elgaard Thorup , Leif Østergaard , Merete Nordentoft , Martin Dietz
{"title":"有精神分裂症或躁郁症家族高风险的青春期前儿童心理网络中的大脑激活和异常有效连接。","authors":"Lotte Veddum , Vibeke Bliksted , Yuan Zhou , Anna Krogh Andreassen , Christina Bruun Knudsen , Aja Neergaard Greve , Nanna Lawaetz Steffensen , Merete Birk , Nicoline Hemager , Julie Marie Brandt , Maja Gregersen , Line Korsgaard Johnsen , Kit Melissa Larsen , William Frans Christiaan Baaré , Kathrine Skak Madsen , Hartwig Roman Siebner , Kerstin Jessica Plessen , Anne Amalie Elgaard Thorup , Leif Østergaard , Merete Nordentoft , Martin Dietz","doi":"10.1016/j.bpsc.2024.08.004","DOIUrl":null,"url":null,"abstract":"<div><h3>Background</h3><div>Schizophrenia and bipolar disorder are characterized by social cognitive impairments, and recent research has identified alterations of the social brain. However, it is unknown whether familial high risk (FHR) of these disorders is associated with neurobiological alterations already present in childhood.</div></div><div><h3>Methods</h3><div>As part of the Danish High Risk and Resilience Study–VIA 11, we examined children at FHR of schizophrenia (<em>n</em> = 121, 50% female) or bipolar disorder (<em>n</em> = 75, 47% female) and population-based control children (PBCs) (<em>n</em> = 128, 48% female). Using functional magnetic resonance imaging and dynamic causal modeling, we investigated brain activation and effective connectivity during the social cognition paradigm from the Human Connectome Project.</div></div><div><h3>Results</h3><div>We found similar activation of the mentalizing network across groups, including visual area V5, the dorsomedial prefrontal cortex, and the posterior superior temporal sulcus (pSTS). Nonetheless, both FHR groups showed aberrant brain connectivity in the form of increased feedforward connectivity from left V5 to pSTS compared with PBCs. Children at FHR of schizophrenia had reduced intrinsic connectivity in bilateral V5 compared with PBCs, whereas children at FHR of bipolar disorder showed increased reciprocal connectivity between the left dorsomedial prefrontal cortex and the pSTS, increased intrinsic connectivity in the right pSTS, and reduced feedforward connectivity from the right pSTS to the dorsomedial prefrontal cortex compared with PBCs.</div></div><div><h3>Conclusions</h3><div>Our results provide first-time evidence of aberrant brain connectivity in the mentalizing network of children at FHR of schizophrenia or FHR of bipolar disorder. Longitudinal research is warranted to clarify whether aberrant brain connectivity during mentalizing constitutes an endophenotype associated with the development of a mental disorder later in life.</div></div>","PeriodicalId":54231,"journal":{"name":"Biological Psychiatry-Cognitive Neuroscience and Neuroimaging","volume":"10 1","pages":"Pages 68-79"},"PeriodicalIF":5.7000,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Brain Activation and Aberrant Effective Connectivity in the Mentalizing Network of Preadolescent Children at Familial High Risk of Schizophrenia or Bipolar Disorder\",\"authors\":\"Lotte Veddum , Vibeke Bliksted , Yuan Zhou , Anna Krogh Andreassen , Christina Bruun Knudsen , Aja Neergaard Greve , Nanna Lawaetz Steffensen , Merete Birk , Nicoline Hemager , Julie Marie Brandt , Maja Gregersen , Line Korsgaard Johnsen , Kit Melissa Larsen , William Frans Christiaan Baaré , Kathrine Skak Madsen , Hartwig Roman Siebner , Kerstin Jessica Plessen , Anne Amalie Elgaard Thorup , Leif Østergaard , Merete Nordentoft , Martin Dietz\",\"doi\":\"10.1016/j.bpsc.2024.08.004\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><h3>Background</h3><div>Schizophrenia and bipolar disorder are characterized by social cognitive impairments, and recent research has identified alterations of the social brain. However, it is unknown whether familial high risk (FHR) of these disorders is associated with neurobiological alterations already present in childhood.</div></div><div><h3>Methods</h3><div>As part of the Danish High Risk and Resilience Study–VIA 11, we examined children at FHR of schizophrenia (<em>n</em> = 121, 50% female) or bipolar disorder (<em>n</em> = 75, 47% female) and population-based control children (PBCs) (<em>n</em> = 128, 48% female). Using functional magnetic resonance imaging and dynamic causal modeling, we investigated brain activation and effective connectivity during the social cognition paradigm from the Human Connectome Project.</div></div><div><h3>Results</h3><div>We found similar activation of the mentalizing network across groups, including visual area V5, the dorsomedial prefrontal cortex, and the posterior superior temporal sulcus (pSTS). Nonetheless, both FHR groups showed aberrant brain connectivity in the form of increased feedforward connectivity from left V5 to pSTS compared with PBCs. Children at FHR of schizophrenia had reduced intrinsic connectivity in bilateral V5 compared with PBCs, whereas children at FHR of bipolar disorder showed increased reciprocal connectivity between the left dorsomedial prefrontal cortex and the pSTS, increased intrinsic connectivity in the right pSTS, and reduced feedforward connectivity from the right pSTS to the dorsomedial prefrontal cortex compared with PBCs.</div></div><div><h3>Conclusions</h3><div>Our results provide first-time evidence of aberrant brain connectivity in the mentalizing network of children at FHR of schizophrenia or FHR of bipolar disorder. Longitudinal research is warranted to clarify whether aberrant brain connectivity during mentalizing constitutes an endophenotype associated with the development of a mental disorder later in life.</div></div>\",\"PeriodicalId\":54231,\"journal\":{\"name\":\"Biological Psychiatry-Cognitive Neuroscience and Neuroimaging\",\"volume\":\"10 1\",\"pages\":\"Pages 68-79\"},\"PeriodicalIF\":5.7000,\"publicationDate\":\"2025-01-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Biological Psychiatry-Cognitive Neuroscience and Neuroimaging\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S2451902224002398\",\"RegionNum\":2,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q1\",\"JCRName\":\"NEUROSCIENCES\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Biological Psychiatry-Cognitive Neuroscience and Neuroimaging","FirstCategoryId":"3","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S2451902224002398","RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"NEUROSCIENCES","Score":null,"Total":0}
Brain Activation and Aberrant Effective Connectivity in the Mentalizing Network of Preadolescent Children at Familial High Risk of Schizophrenia or Bipolar Disorder
Background
Schizophrenia and bipolar disorder are characterized by social cognitive impairments, and recent research has identified alterations of the social brain. However, it is unknown whether familial high risk (FHR) of these disorders is associated with neurobiological alterations already present in childhood.
Methods
As part of the Danish High Risk and Resilience Study–VIA 11, we examined children at FHR of schizophrenia (n = 121, 50% female) or bipolar disorder (n = 75, 47% female) and population-based control children (PBCs) (n = 128, 48% female). Using functional magnetic resonance imaging and dynamic causal modeling, we investigated brain activation and effective connectivity during the social cognition paradigm from the Human Connectome Project.
Results
We found similar activation of the mentalizing network across groups, including visual area V5, the dorsomedial prefrontal cortex, and the posterior superior temporal sulcus (pSTS). Nonetheless, both FHR groups showed aberrant brain connectivity in the form of increased feedforward connectivity from left V5 to pSTS compared with PBCs. Children at FHR of schizophrenia had reduced intrinsic connectivity in bilateral V5 compared with PBCs, whereas children at FHR of bipolar disorder showed increased reciprocal connectivity between the left dorsomedial prefrontal cortex and the pSTS, increased intrinsic connectivity in the right pSTS, and reduced feedforward connectivity from the right pSTS to the dorsomedial prefrontal cortex compared with PBCs.
Conclusions
Our results provide first-time evidence of aberrant brain connectivity in the mentalizing network of children at FHR of schizophrenia or FHR of bipolar disorder. Longitudinal research is warranted to clarify whether aberrant brain connectivity during mentalizing constitutes an endophenotype associated with the development of a mental disorder later in life.
期刊介绍：
Biological Psychiatry: Cognitive Neuroscience and Neuroimaging is an official journal of the Society for Biological Psychiatry, whose purpose is to promote excellence in scientific research and education in fields that investigate the nature, causes, mechanisms, and treatments of disorders of thought, emotion, or behavior. In accord with this mission, this peer-reviewed, rapid-publication, international journal focuses on studies using the tools and constructs of cognitive neuroscience, including the full range of non-invasive neuroimaging and human extra- and intracranial physiological recording methodologies. It publishes both basic and clinical studies, including those that incorporate genetic data, pharmacological challenges, and computational modeling approaches. The journal publishes novel results of original research which represent an important new lead or significant impact on the field. Reviews and commentaries that focus on topics of current research and interest are also encouraged.
京公网安备 11010802042870号
京ICP备2023020795号-1
分享
求助内容：
应助结果提醒方式：
扫码关注我们
