集群阻力训练对老年血液透析受试者骨矿物质密度和骨代谢指标的影响:一项试点研究。

IF 3.5 2区 医学 Q2 ENDOCRINOLOGY & METABOLISM Bone Pub Date : 2024-08-23 DOI:10.1016/j.bone.2024.117240
Bruno Magalhães de Castro , Thiago dos Santos Rosa , Thaís Branquinho de Araújo , Hugo de Luca Corrêa , Lysleine Alves de Deus , Rodrigo Vanerson Passos Neves , Andrea Lucena Reis , Rafael Lavarini dos Santos , Jéssica Mycaelle da Silva Barbosa , Fernando de Sousa Honorato , Vitória Marra da Motta Vilalva Mestrinho , Milton Rocha de Moraes , Carmen Tzanno-Martins , Jonato Prestes
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引用次数: 0

摘要

慢性肾脏病(CKD)与一系列矿物质骨骼紊乱有关,这是因为副肾激素分泌增加,从而提高了破骨细胞的活性,清除了骨骼中的钙和磷。然而,文献中缺乏对不同阻力训练(RT)方法(如集群训练)在这类人群中的可行性研究。因此,本研究旨在比较传统阻力训练方案和集群阻力训练方案对患有慢性肾脏病的老年受试者的骨矿物质密度(BMD)T 值、BMD 总值、股骨 BMD、L3-L4 BMD、股骨颈 BMD、Klotho、FGF23、Klotho - FGF23 比值、Sclerostin、维生素 D、磷和钙的影响。78 名老年受试者(年龄:57.55±4.06 岁,体重:72.26±13.96 千克,身体质量指数:26.73±2.97 千克)进行了研究:他们被随机分为对照组(CG,n = 26)、传统 RT 组(RT,n = 26)和集群 RT 组(RT-CS,n = 26)。受试者每周完成三次为期24周的RT训练,分别在血液透析前1小时和30分钟进行,每次训练持续约60至80分钟。总 BMD、股骨 BMD、L3-L4 BMD 和股骨颈 BMD 存在组与时间的交互作用,RT 组和 RT-CS 组(前与后)的改善情况表明了这一点。只有股骨 BMD 与 CG 相比存在差异。最小临床重要差异(MCID)值显示,RT-CS 组受试者对总 BMD、股骨 BMD、klotho、FGF23、硬骨素、维生素 D 和钙的反应更灵敏。总之,RT 可作为治疗慢性肾功能衰竭的非药物补充策略。RT-CS可能对这些受试者有用,因为在这种类型的训练中发现了更多的应答者。
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Effects of cluster set resistance training on bone mineral density and markers of bone metabolism in older hemodialysis subjects: A pilot study

Chronic kidney disease (CKD) is associated with a series of mineral bone disturbances due to increased production of parathormone which increases the activity of osteoclasts, removing calcium and phosphorous from the bones. However, the literature lacks investigations on the feasibility of different resistance training (RT) methods, such as cluster-sets, in this population. Thus, the aim of the present study was to compare traditional versus cluster-set RT protocols on bone mineral density (BMD) T-score, BMD Total, femur BMD, L3-L4 BMD, femoral neck BMD, Klotho, FGF23, Klotho - FGF23 ratio, Sclerostin, vitamin D, phosphorous and calcium in older subjects with CKD. Seventy-eight older subjects (age: 57.55 ± 4.06 years, body mass: 72.26 ± 13.96 kg, body mass index: 26.73 ± 2.97 kg/m2) with CKD undergoing maintenance hemodialysis were randomly divided into control group (CG, n = 26), traditional RT (RT, n = 26) and cluster-set RT (RT-CS, n = 26) groups. Subjects completed 24 weeks of RT three times per week, 1 h and 30 min before the hemodialysis session, and each training lasted around 60 to 80 min. There was a group×time interaction for total BMD, femur BMD, L3-L4 BMD, and femoral neck BMD, revealed by improvements for RT and RT-CS groups (pre versus post). Only femur BMD displayed differences as compared with the CG. Minimum clinically important difference (MCID) values revealed more responsive subjects in the RT-CS group for total BMD, femur BMD, klotho, FGF23, sclerostin, Vitamin D and calcium. In conclusion, RT can be used as a non-pharmacological complementary strategy for the treatment of CKD. RT-CS may be useful for these subjects as more responders were found for this type of training.

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来源期刊
Bone
Bone 医学-内分泌学与代谢
CiteScore
8.90
自引率
4.90%
发文量
264
审稿时长
30 days
期刊介绍: BONE is an interdisciplinary forum for the rapid publication of original articles and reviews on basic, translational, and clinical aspects of bone and mineral metabolism. The Journal also encourages submissions related to interactions of bone with other organ systems, including cartilage, endocrine, muscle, fat, neural, vascular, gastrointestinal, hematopoietic, and immune systems. Particular attention is placed on the application of experimental studies to clinical practice.
期刊最新文献
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