良性疾病与妇科恶性肿瘤子宫切除术后尿失禁和脱垂的发生率。

Jeannine M Miranne, Iwona Gabriel, Maura Kelly, Alexa Courtepatte, Vatche A Minassian
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引用次数: 0

摘要

目的估计良性疾病和妇科恶性肿瘤子宫切除术后 UI 和 POP 的发病率。这是一项回顾性队列病历审查研究。研究对象为 2006-2010 年间两个主要的城市三级医疗中心。因良性或恶性指征接受子宫切除术的≥18岁女性:根据患者在门诊笔记中的报告、ICD-9 UI 和 POP 诊断代码以及 CPT 治疗代码确定是否存在 UI 和 POP。子宫切除术后 UI 和 POP 的发病率以及子宫切除术后 UI 和 POP 的发病时间:1363名(55%)妇女因良性疾病接受了子宫切除术,1107名(45%)妇女因恶性肿瘤接受了子宫切除术。良性组与恶性组的术后尿失禁和子宫内膜异位症发病率分别为 15.1% 对 11.1% (P = 0.001)和 12.1% 对 2.8% (P < 0.001)。在没有术前UI的患者子集中,良性组发生UI的中位时间为3.5年,而恶性组为3年(P < 0.001)。在没有术前POP的患者子集中,良性组发生POP的中位时间为5年,恶性组为3.5年(P < 0.001)。在对混杂因素进行调整后,或考虑到子宫切除术前UI或POP时,各组间发生UI或POP的风险无明显差异:结论:如果考虑到子宫切除术前的 UI 或 POP,子宫切除术后 UI 或 POP 的发病率没有差异。
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Prevalence of urinary incontinence and prolapse after hysterectomy for benign disease versus gynecologic malignancy.

Objectives: To estimate the prevalence of UI and POP after hysterectomy for benign disease and gynecologic malignancy. This is a retrospective cohort chart review study. Two major urban tertiary care centers between 2006-2010. Women ≥ 18 years undergoing hysterectomy for benign or malignant indications.

Material and methods: Presence of UI and POP was based on patient report in clinic notes, ICD-9 UI and POP diagnosis codes, and CPT codes for treatment. Prevalence of UI and POP after hysterectomy and time to development of UI and POP after hysterectomy.

Results: 1363 (55%) women underwent hysterectomy for benign disease while 1107 (45%) had a hysterectomy for malignancy. Postoperative prevalence of UI and POP in the benign versus the malignant group was 15.1% vs 11.1% (p = 0.001), and 12.1% vs 2.8%, (p < 0.001), respectively. The median time to development of UI in the subset of patients without preoperative UI was 3.5 years in the benign group vs 3 years in the malignant group (p < 0.001). The median time to development of POP in the subset of patients without preoperative POP was 5 years in the benign group and 3.5 years in the malignant group (p < 0.001). There was no significant difference in the risk of developing UI or POP between groups after adjusting for confounders or when accounting for pre-hysterectomy UI or POP.

Conclusions: When pre-hysterectomy UI or POP is taken into consideration, there is no difference in the prevalence of post-hysterectomy UI or POP.

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