{"title":"2H(甲基)-3-烷基-4-氧代-3,4-二氢喹唑啉-6-磺酰胺的设计和一步法合成","authors":"","doi":"10.1016/j.cdc.2024.101160","DOIUrl":null,"url":null,"abstract":"<div><p>2H(Methyl)-3-alkylquinazolin-4(3H)-ones were synthesized by reactions of 2H(methyl)quinazolin-4(3H)-ones with alkyl halides. The obtained 2H(methyl)-3-alkylquinazolin-4(3H)-ones were subjected to one-pot synthesis in the presence of chlorosulfonic acid and ammonia, primary sulfonamides among bicyclic quinazolines were synthesized and were characterized by <sup>1</sup>H NMR, <sup>13</sup>C NMR, IR and mass spectral data. The crystal structure of 2-methyl-3‑butyl‑4-oxo-3,4-dihydroquinazoline-6-sulfonamide was determined by the single-crystal X-ray diffraction method at 293 K.</p></div>","PeriodicalId":269,"journal":{"name":"Chemical Data Collections","volume":null,"pages":null},"PeriodicalIF":2.2180,"publicationDate":"2024-08-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Design and one-pot synthesis of 2H(methyl)-3-alkyl-4-oxo-3,4-dihydroquinazoline-6-sulfonamides\",\"authors\":\"\",\"doi\":\"10.1016/j.cdc.2024.101160\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><p>2H(Methyl)-3-alkylquinazolin-4(3H)-ones were synthesized by reactions of 2H(methyl)quinazolin-4(3H)-ones with alkyl halides. The obtained 2H(methyl)-3-alkylquinazolin-4(3H)-ones were subjected to one-pot synthesis in the presence of chlorosulfonic acid and ammonia, primary sulfonamides among bicyclic quinazolines were synthesized and were characterized by <sup>1</sup>H NMR, <sup>13</sup>C NMR, IR and mass spectral data. The crystal structure of 2-methyl-3‑butyl‑4-oxo-3,4-dihydroquinazoline-6-sulfonamide was determined by the single-crystal X-ray diffraction method at 293 K.</p></div>\",\"PeriodicalId\":269,\"journal\":{\"name\":\"Chemical Data Collections\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":2.2180,\"publicationDate\":\"2024-08-15\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Chemical Data Collections\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S240583002400048X\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q2\",\"JCRName\":\"Chemistry\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Chemical Data Collections","FirstCategoryId":"1085","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S240583002400048X","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"Chemistry","Score":null,"Total":0}
引用次数: 0
摘要
通过 2H(甲基)喹唑啉-4(3H)-酮与烷基卤化物的反应合成了 2H(甲基)-3-烷基喹唑啉-4(3H)-酮。得到的 2H(甲基)-3-烷基喹唑啉-4(3H)-酮在氯磺酸和氨存在下进行了一锅合成，合成了双环喹唑啉类中的初级磺酰胺，并通过 1H NMR、13C NMR、IR 和质谱数据对其进行了表征。在 293 K 温度下，用单晶 X 射线衍射法测定了 2-甲基-3-丁基-4-氧代-3,4-二氢喹唑啉-6-磺酰胺的晶体结构。
Design and one-pot synthesis of 2H(methyl)-3-alkyl-4-oxo-3,4-dihydroquinazoline-6-sulfonamides
2H(Methyl)-3-alkylquinazolin-4(3H)-ones were synthesized by reactions of 2H(methyl)quinazolin-4(3H)-ones with alkyl halides. The obtained 2H(methyl)-3-alkylquinazolin-4(3H)-ones were subjected to one-pot synthesis in the presence of chlorosulfonic acid and ammonia, primary sulfonamides among bicyclic quinazolines were synthesized and were characterized by 1H NMR, 13C NMR, IR and mass spectral data. The crystal structure of 2-methyl-3‑butyl‑4-oxo-3,4-dihydroquinazoline-6-sulfonamide was determined by the single-crystal X-ray diffraction method at 293 K.
期刊介绍：
Chemical Data Collections (CDC) provides a publication outlet for the increasing need to make research material and data easy to share and re-use. Publication of research data with CDC will allow scientists to: -Make their data easy to find and access -Benefit from the fast publication process -Contribute to proper data citation and attribution -Publish their intermediate and null/negative results -Receive recognition for the work that does not fit traditional article format. The research data will be published as ''data articles'' that support fast and easy submission and quick peer-review processes. Data articles introduced by CDC are short self-contained publications about research materials and data. They must provide the scientific context of the described work and contain the following elements: a title, list of authors (plus affiliations), abstract, keywords, graphical abstract, metadata table, main text and at least three references. The journal welcomes submissions focusing on (but not limited to) the following categories of research output: spectral data, syntheses, crystallographic data, computational simulations, molecular dynamics and models, physicochemical data, etc.
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