用于肝细胞癌成像和手术导航的谷胱甘肽和粘度双锁响应荧光探针。

IF 4.3 2区化学 Q2 CHEMISTRY, MULTIDISCIPLINARY Chemical Communications Pub Date : 2024-08-27 DOI:10.1039/D4CC03582H

Wen Zhang, Min Zhang, Mengmei Li, Xin Wang, Ping Li and Bo Tang

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引用次数: 0

摘要

肝细胞癌（HCC）的早期诊断和精确治疗对人类健康至关重要。因此，针对 HCC 的潜在标志物--谷胱甘肽（GSH）和粘度，我们构建了一种由 GSH/粘度级联激活的荧光探针（PG-V）。PG-V 具有优异的光物理特性和生物相容性，可特异性地照射肿瘤组织，实现对 HCC 的荧光成像和成像引导的肿瘤切除。

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Glutathione and viscosity double-locked response fluorescent probe for imaging and surgical navigation of hepatocellular carcinoma†

Early diagnosis and precise treatment of hepatocellular carcinoma (HCC) are crucial for human health. Therefore, addressing the potential markers of HCC, glutathione (GSH) and viscosity, we constructed a fluorescent probe (PG-V) activated cascadically by GSH/viscosity. PG-V possessed excellent photophysical properties and biocompatibility, and could specifically illuminate tumor tissue, achieving fluorescence imaging of HCC, and imaging-guided tumor resection.

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来源期刊

Chemical Communications 化学-化学综合

CiteScore

8.60

自引率

4.10%

发文量

2705

审稿时长

1.4 months

期刊介绍： ChemComm (Chemical Communications) is renowned as the fastest publisher of articles providing information on new avenues of research, drawn from all the world''s major areas of chemical research.