萌发酵母细胞周期中的蛋白质合成模式:可变还是恒定?

IF 4.1 3区 生物学 Q2 CELL BIOLOGY Microbial Cell Pub Date : 2024-08-20 eCollection Date: 2024-01-01 DOI:10.15698/mic2024.08.835
Eun-Gyu No, Heidi M Blank, Michael Polymenis
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引用次数: 0

摘要

蛋白质是增殖细胞的主要大分子成分,蛋白质合成被视为细胞生长的主要指标。虽然有著名的蛋白质水平在细胞周期中呈周期性变化的例子(如细胞周期蛋白),但人们认为大多数蛋白质的浓度在细胞周期中不会发生变化,但最近的一些研究结果对这一观点提出了挑战。本文的重点是芽殖酵母(Saccharomyces cerevisiae)中的 "大量 "蛋白质,特别是其合成速度。
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Patterns of protein synthesis in the budding yeast cell cycle: variable or constant?

Proteins are the principal macromolecular constituent of proliferating cells, and protein synthesis is viewed as a primary metric of cell growth. While there are celebrated examples of proteins whose levels are periodic in the cell cycle (e.g., cyclins), the concentration of most proteins was not thought to change in the cell cycle, but some recent results challenge this notion. The 'bulk' protein is the focus of this article, specifically the rate of its synthesis, in the budding yeast Saccharomyces cerevisiae.

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来源期刊
Microbial Cell
Microbial Cell Multiple-
CiteScore
6.40
自引率
0.00%
发文量
32
审稿时长
12 weeks
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