富含芦根提取物和色氨酸的牛奶对改善有睡眠问题的成年人主观睡眠质量的效果:随机双盲对照试验》。

IF 2.1 Q3 CLINICAL NEUROLOGY Clocks & Sleep Pub Date : 2024-08-09 DOI:10.3390/clockssleep6030028
Silvia Pérez-Piñero, Juan Carlos Muñoz-Carrillo, Jon Echepare-Taberna, Macarena Muñoz-Cámara, Cristina Herrera-Fernández, Vicente Ávila-Gandía, María Heres Fernández Ladreda, Javier Menéndez Martínez, Francisco Javier López-Román
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引用次数: 0

摘要

我们进行了一项随机、双盲对照研究,以评估单独或与色氨酸一起摄入 250 毫升富含水飞蓟的无乳糖脱脂牛奶与非富含水飞蓟的牛奶(对照组)相比,对有睡眠问题的健康成年人主观睡眠质量的影响。补充时间为 90 天。52 名符合条件的受试者被分配到灰树花 250 毫克、灰树花 250 毫克加色氨酸 175 毫克、灰树花 600 毫克和对照组的研究组,每组 13 人。研究假设,在改善睡眠相关变量方面,灰树花加色氨酸可能优于单用灰树花。与对照组相比,三个实验组的睡眠质量视觉模拟量表(VAS)的变化明显更高(p = 0.014)。所有实验组的皮茨堡睡眠质量指数(PSQI)分量表都有所改善,但组间差异不明显。与对照组相比,三个实验组的失眠严重程度指数下降幅度更大,尤其是服用灰黄霉素 600 毫克的实验组。三个实验组的白天嗜睡也有所减少。焦虑水平和晨间活力问卷调查未观察到变化。研究产品没有引起身体成分的变化,并且具有良好的耐受性和安全性。数据并不支持假设,因为灰树花和色氨酸的组合在改善睡眠质量方面并没有显示出比单独使用灰树花更大的益处。不过,与安慰剂组相比,含有芦荟的三个实验组的结果更为有利。
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Effectiveness of Enriched Milk with Ashwagandha Extract and Tryptophan for Improving Subjective Sleep Quality in Adults with Sleep Problems: A Randomized Double-Blind Controlled Trial.

A randomized, double-blind and controlled study was conducted to assess the effectiveness of the intake of 250 mL of lactose-free skimmed milk enriched with ashwagandha (Withania somnifera) alone or combined with tryptophan vs. non-enriched milk (control) on the subjective quality of sleep in healthy adults with sleep problems. The duration of supplementation was 90 days. Fifty-two eligible subjects were assigned to the study arms of ashwagandha 250 mg, ashwagandha 250 mg plus tryptophan 175 mg, ashwagandha 600 mg, and control with 13 subjects in each group. It was hypothesized that ashwagandha plus tryptophan could be superior to ashwagandha alone for improving sleep-related variables. Changes in the visual analogue scale (VAS) for sleep quality were significantly higher in the three experimental groups as compared with controls (p = 0.014). Improvements in the subscales of the Pittsburg Sleep Quality Index (PSQI) were found in all groups, but between-group differences were not significant. In the index of insomnia severity, decreases were higher in the three experimental groups as compared with controls especially in the group of ashwagandha 600 mg. Daytime somnolence was also reduced in the three experimental groups. Changes in anxiety levels and Morningness-Eveningness Questionnaire were not observed. The study products did not elicit changes in body composition and were well tolerated and safe. The data did not support the hypothesis, as the combination of ashwagandha and tryptophan did not show greater benefits in improving sleep quality than ashwagandha alone. However, the results from the three experimental groups containing ashwagandha were more favorable compared to the placebo group.

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来源期刊
Clocks & Sleep
Clocks & Sleep Multiple-
CiteScore
4.40
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审稿时长
7 weeks
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