自膨胀金属支架作为结肠癌梗阻患者手术的桥梁对长期生存结果的影响:现状与前景。

Hao-Yu Zhang, Zhen-Jun Wang, Jia-Gang Han
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引用次数: 0

摘要

自自膨胀金属支架(SEMS)首次应用于急性结肠癌梗阻以来,已清楚地显示了放置 SEMS 后初次吻合率的提高和生活质量的改善。然而,事实证明 SEMS 与较高的复发率有关。尽管多项试验表明,接受 SEMS 置入术的患者的总生存率和无病生存率与接受急诊手术的患者相似,但梗阻和高复发率仍引发了许多担忧。从 SEMS 到手术的最佳时间间隔仍存在争议。一些研究建议 SEMS 置入与择期手术之间的时间间隔为 2 周左右。也有研究建议延长SEMS插入到择期手术和新辅助化疗(NAC)的时间间隔。SEMS-NAC 在改善急性结肠癌梗阻患者的手术和长期生存预后方面可能具有优势,是治疗急性结肠癌梗阻的一种可选方法。
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Impact of self-expanding metal stents on long-term survival outcomes as a bridge to surgery in patients with colon cancer obstruction: Current state and future prospects.

Since self-expanding metal stents (SEMS) were first introduced in acute colon cancer obstruction, the increased rate of primary anastomosis and improved quality of life following SEMS placement have been clearly shown. However, it was demonstrated that SEMS are associated with higher recurrence rates. Although several trials have shown that overall and disease-free survival in patients following SEMS placement is similar with patients undergoing emergency surgery, obstruction and a high incidence of recurrence imposed many concerns. The optimal time interval from SEMS to surgery is still a matter of debate. Some studies have recommended a time interval of ~2 weeks between SEMS insertion and elective surgery. A prolonged interval of time from SEMS insertion to elective surgery and the administration of neoadjuvant chemotherapy (NAC) has been proposed. SEMS-NAC might have advantages for improving the surgical and long-term survival outcomes of patients with acute colon cancer obstruction, which is an optional approach in the management of acute colon cancer obstruction.

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