Sana Ahuja, Marzieh Fattahi-Darghlou, Sufian Zaheer, Rhea Ahuja
{"title":"帕氏细胞病理学协会系统报告呼吸道细胞学的诊断准确性:系统回顾与元分析》。","authors":"Sana Ahuja, Marzieh Fattahi-Darghlou, Sufian Zaheer, Rhea Ahuja","doi":"10.1159/000541139","DOIUrl":null,"url":null,"abstract":"<p><strong>Introduction: </strong>This study conducts the first meta-analysis to evaluate the diagnostic accuracy and the aggregated risk of malignancy associated with each category of the Papanicolaou Society of Cytopathology (PSC) system for reporting respiratory cytology.</p><p><strong>Methods: </strong>A systematic search was conducted in PubMed, Scopus, and Web of Science using the keywords \"(Lung, Respiratory specimens) AND (Papanicolaou Society of Cytopathology System).\" Articles were assessed for risk of bias using the QUADAS-2 tool. After excluding inadequate samples, sensitivity and specificity for various cut-off points. Summary receiver operating characteristic curves and diagnostic odds ratios were pooled to assess diagnostic accuracy.</p><p><strong>Results: </strong>Five studies, totaling 3,489 cases, were included. Sensitivity and specificity for the \"Atypical and higher risk categories\" considered positive were 60% (95% CI, 51-68%) and 87% (95% CI, 81-92%), respectively. For the \"Suspicious for malignancy and higher risk categories\" considered positive, sensitivity and specificity were 49% (95% CI, 40-58%) and 95% (95% CI, 92-97%), respectively. Sensitivity and specificity for the \"Malignant\" category considered positive for malignancy were 42% (95% CI, 33-52%) and 97% (95% CI, 92-99%), respectively. The pooled area under the curve ranged from 68 to 75% for each cut-off.</p><p><strong>Conclusion: </strong>This meta-analysis underscores the PSC system's accuracy in reporting respiratory cytology. It highlights the diagnostic importance of the \"Suspicious\" and \"Malignant\" categories in identifying malignancy, and the utility of the \"Atypical\" category for initial screening. These findings support the PSC system's role in enhancing diagnostic accuracy and clinical decision-making in respiratory cytology.</p>","PeriodicalId":6959,"journal":{"name":"Acta Cytologica","volume":" ","pages":"450-464"},"PeriodicalIF":1.6000,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Diagnostic Accuracy of Papanicolaou Society of Cytopathology System for Reporting Respiratory Cytology: A Systematic Review and Meta-Analysis.\",\"authors\":\"Sana Ahuja, Marzieh Fattahi-Darghlou, Sufian Zaheer, Rhea Ahuja\",\"doi\":\"10.1159/000541139\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Introduction: </strong>This study conducts the first meta-analysis to evaluate the diagnostic accuracy and the aggregated risk of malignancy associated with each category of the Papanicolaou Society of Cytopathology (PSC) system for reporting respiratory cytology.</p><p><strong>Methods: </strong>A systematic search was conducted in PubMed, Scopus, and Web of Science using the keywords \\\"(Lung, Respiratory specimens) AND (Papanicolaou Society of Cytopathology System).\\\" Articles were assessed for risk of bias using the QUADAS-2 tool. After excluding inadequate samples, sensitivity and specificity for various cut-off points. Summary receiver operating characteristic curves and diagnostic odds ratios were pooled to assess diagnostic accuracy.</p><p><strong>Results: </strong>Five studies, totaling 3,489 cases, were included. Sensitivity and specificity for the \\\"Atypical and higher risk categories\\\" considered positive were 60% (95% CI, 51-68%) and 87% (95% CI, 81-92%), respectively. For the \\\"Suspicious for malignancy and higher risk categories\\\" considered positive, sensitivity and specificity were 49% (95% CI, 40-58%) and 95% (95% CI, 92-97%), respectively. Sensitivity and specificity for the \\\"Malignant\\\" category considered positive for malignancy were 42% (95% CI, 33-52%) and 97% (95% CI, 92-99%), respectively. The pooled area under the curve ranged from 68 to 75% for each cut-off.</p><p><strong>Conclusion: </strong>This meta-analysis underscores the PSC system's accuracy in reporting respiratory cytology. It highlights the diagnostic importance of the \\\"Suspicious\\\" and \\\"Malignant\\\" categories in identifying malignancy, and the utility of the \\\"Atypical\\\" category for initial screening. These findings support the PSC system's role in enhancing diagnostic accuracy and clinical decision-making in respiratory cytology.</p>\",\"PeriodicalId\":6959,\"journal\":{\"name\":\"Acta Cytologica\",\"volume\":\" \",\"pages\":\"450-464\"},\"PeriodicalIF\":1.6000,\"publicationDate\":\"2024-01-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Acta Cytologica\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.1159/000541139\",\"RegionNum\":4,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"2024/8/27 0:00:00\",\"PubModel\":\"Epub\",\"JCR\":\"Q3\",\"JCRName\":\"PATHOLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Acta Cytologica","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1159/000541139","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2024/8/27 0:00:00","PubModel":"Epub","JCR":"Q3","JCRName":"PATHOLOGY","Score":null,"Total":0}
Diagnostic Accuracy of Papanicolaou Society of Cytopathology System for Reporting Respiratory Cytology: A Systematic Review and Meta-Analysis.
Introduction: This study conducts the first meta-analysis to evaluate the diagnostic accuracy and the aggregated risk of malignancy associated with each category of the Papanicolaou Society of Cytopathology (PSC) system for reporting respiratory cytology.
Methods: A systematic search was conducted in PubMed, Scopus, and Web of Science using the keywords "(Lung, Respiratory specimens) AND (Papanicolaou Society of Cytopathology System)." Articles were assessed for risk of bias using the QUADAS-2 tool. After excluding inadequate samples, sensitivity and specificity for various cut-off points. Summary receiver operating characteristic curves and diagnostic odds ratios were pooled to assess diagnostic accuracy.
Results: Five studies, totaling 3,489 cases, were included. Sensitivity and specificity for the "Atypical and higher risk categories" considered positive were 60% (95% CI, 51-68%) and 87% (95% CI, 81-92%), respectively. For the "Suspicious for malignancy and higher risk categories" considered positive, sensitivity and specificity were 49% (95% CI, 40-58%) and 95% (95% CI, 92-97%), respectively. Sensitivity and specificity for the "Malignant" category considered positive for malignancy were 42% (95% CI, 33-52%) and 97% (95% CI, 92-99%), respectively. The pooled area under the curve ranged from 68 to 75% for each cut-off.
Conclusion: This meta-analysis underscores the PSC system's accuracy in reporting respiratory cytology. It highlights the diagnostic importance of the "Suspicious" and "Malignant" categories in identifying malignancy, and the utility of the "Atypical" category for initial screening. These findings support the PSC system's role in enhancing diagnostic accuracy and clinical decision-making in respiratory cytology.
期刊介绍:
With articles offering an excellent balance between clinical cytology and cytopathology, ''Acta Cytologica'' fosters the understanding of the pathogenetic mechanisms behind cytomorphology and thus facilitates the translation of frontline research into clinical practice. As the official journal of the International Academy of Cytology and affiliated to over 50 national cytology societies around the world, ''Acta Cytologica'' evaluates new and existing diagnostic applications of scientific advances as well as their clinical correlations. Original papers, review articles, meta-analyses, novel insights from clinical practice, and letters to the editor cover topics from diagnostic cytopathology, gynecologic and non-gynecologic cytopathology to fine needle aspiration, molecular techniques and their diagnostic applications. As the perfect reference for practical use, ''Acta Cytologica'' addresses a multidisciplinary audience practicing clinical cytopathology, cell biology, oncology, interventional radiology, otorhinolaryngology, gastroenterology, urology, pulmonology and preventive medicine.