帕氏细胞病理学协会系统报告呼吸道细胞学的诊断准确性:系统回顾与元分析》。

IF 1.6 4区 医学 Q3 PATHOLOGY Acta Cytologica Pub Date : 2024-01-01 Epub Date: 2024-08-27 DOI:10.1159/000541139
Sana Ahuja, Marzieh Fattahi-Darghlou, Sufian Zaheer, Rhea Ahuja
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引用次数: 0

摘要

引言 本研究首次进行了荟萃分析,以评估用于报告呼吸道细胞学检查的巴氏细胞病理学会(PSC)系统各分类的诊断准确性和恶性肿瘤的总体风险。方法 使用关键词"(肺、呼吸道标本)和(巴氏细胞病理学协会系统)"在 PubMed、Scopus 和 Web of Science 中进行系统检索。使用 QUADAS-2 工具对文章进行偏倚风险评估。剔除不充分样本后,确定不同截断点的敏感性和特异性。汇总接收者操作特征曲线(sROC)和诊断几率比(DOR)以评估诊断准确性。结果 共纳入了五项研究,共计 3489 个病例。被视为阳性的 "非典型和高风险类别 "的敏感性和特异性分别为 60%(95% CI,51%-68%)和 87%(95% CI,81%-92%)。在 "恶性肿瘤可疑和高风险类别 "中,阳性的敏感性和特异性分别为 49%(95% CI,40%-58%)和 95%(95% CI,92%-97%)。恶性 "类别的敏感性和特异性分别为 42%(95% CI,33%-52%)和 97%(95% CI,92%-99%)。每个临界值的集合曲线下面积(AUC)介于 68% 到 75% 之间。结论 该荟萃分析强调了 PSC 系统在报告呼吸道细胞学方面的准确性。它强调了 "可疑 "和 "恶性 "类别在确定恶性肿瘤方面的诊断重要性,以及 "非典型 "类别在初步筛查方面的实用性。这些研究结果支持 PSC 系统在提高呼吸道细胞学诊断准确性和临床决策方面的作用。
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Diagnostic Accuracy of Papanicolaou Society of Cytopathology System for Reporting Respiratory Cytology: A Systematic Review and Meta-Analysis.

Introduction: This study conducts the first meta-analysis to evaluate the diagnostic accuracy and the aggregated risk of malignancy associated with each category of the Papanicolaou Society of Cytopathology (PSC) system for reporting respiratory cytology.

Methods: A systematic search was conducted in PubMed, Scopus, and Web of Science using the keywords "(Lung, Respiratory specimens) AND (Papanicolaou Society of Cytopathology System)." Articles were assessed for risk of bias using the QUADAS-2 tool. After excluding inadequate samples, sensitivity and specificity for various cut-off points. Summary receiver operating characteristic curves and diagnostic odds ratios were pooled to assess diagnostic accuracy.

Results: Five studies, totaling 3,489 cases, were included. Sensitivity and specificity for the "Atypical and higher risk categories" considered positive were 60% (95% CI, 51-68%) and 87% (95% CI, 81-92%), respectively. For the "Suspicious for malignancy and higher risk categories" considered positive, sensitivity and specificity were 49% (95% CI, 40-58%) and 95% (95% CI, 92-97%), respectively. Sensitivity and specificity for the "Malignant" category considered positive for malignancy were 42% (95% CI, 33-52%) and 97% (95% CI, 92-99%), respectively. The pooled area under the curve ranged from 68 to 75% for each cut-off.

Conclusion: This meta-analysis underscores the PSC system's accuracy in reporting respiratory cytology. It highlights the diagnostic importance of the "Suspicious" and "Malignant" categories in identifying malignancy, and the utility of the "Atypical" category for initial screening. These findings support the PSC system's role in enhancing diagnostic accuracy and clinical decision-making in respiratory cytology.

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来源期刊
Acta Cytologica
Acta Cytologica 生物-病理学
CiteScore
3.70
自引率
11.10%
发文量
46
审稿时长
4-8 weeks
期刊介绍: With articles offering an excellent balance between clinical cytology and cytopathology, ''Acta Cytologica'' fosters the understanding of the pathogenetic mechanisms behind cytomorphology and thus facilitates the translation of frontline research into clinical practice. As the official journal of the International Academy of Cytology and affiliated to over 50 national cytology societies around the world, ''Acta Cytologica'' evaluates new and existing diagnostic applications of scientific advances as well as their clinical correlations. Original papers, review articles, meta-analyses, novel insights from clinical practice, and letters to the editor cover topics from diagnostic cytopathology, gynecologic and non-gynecologic cytopathology to fine needle aspiration, molecular techniques and their diagnostic applications. As the perfect reference for practical use, ''Acta Cytologica'' addresses a multidisciplinary audience practicing clinical cytopathology, cell biology, oncology, interventional radiology, otorhinolaryngology, gastroenterology, urology, pulmonology and preventive medicine.
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