[线粒体铜平衡失调与纤维化疾病的研究进展]。

Q3 Medicine 生理学报 Pub Date : 2024-08-25
Sai-Ya Zhu, Jing Liu, Chen Yu
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引用次数: 0

摘要

铜离子是各种酶的辅助因子,参与多种细胞过程。线粒体是细胞内重要的铜库。以往的综述广泛总结了线粒体铜平衡失调与血液病、心肌病和骨骼肌病之间的关系。然而,有关其与器官纤维化关系的信息却很有限。本文概述了线粒体铜平衡失调在纤维化疾病中的作用和机制,系统阐述了铜的吸收和转运以及线粒体内铜平衡的调节。研究重点是线粒体铜超载和缺乏对纤维化疾病的影响,以及铜螯合剂作为潜在抗纤维化治疗方法的应用。
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[Research progress on mitochondrial copper homeostasis imbalance and fibrosis diseases].

Copper ions serve as co-factors for various enzymes and participate in multiple cellular processes. Mitochondria are essential copper reservoirs within the cell. Previous reviews have extensively summarized the association between mitochondrial copper homeostasis imbalance and hematologic disorders, cardiomyopathies, and skeletal myopathies. However, there is limited information regarding its association with organ fibrosis. This article outlines the role and mechanism of disrupted mitochondrial copper homeostasis in fibrotic diseases, and systematically elaborates copper absorption and transport, as well as the regulation of copper homeostasis within mitochondria. It focuses on the impacts of mitochondrial copper overload and deficiency on fibrotic diseases, and the application of copper chelators as potential anti-fibrotic therapeutic approaches.

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来源期刊
生理学报
生理学报 Medicine-Medicine (all)
CiteScore
1.20
自引率
0.00%
发文量
4820
期刊介绍: Acta Physiologica Sinica (APS) is sponsored by the Chinese Association for Physiological Sciences and Shanghai Institutes of Biological Sciences, Chinese Academy of Sciences (CAS), and is published bimonthly by the Science Press, China. APS publishes original research articles in the field of physiology as well as research contributions from other biomedical disciplines and proceedings of conferences and symposia of physiological sciences. Besides “Original Research Articles”, the journal also provides columns as “Brief Review”, “Rapid Communication”, “Experimental Technique”, and “Letter to the Editor”. Articles are published in either Chinese or English according to authors’ submission.
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