比较 HSV1 和 HSV2 抗体检测与 PCR 在诊断复发性生殖器疱疹中的准确性。

IF 1.9 4区医学 Q3 DERMATOLOGY Clinical, Cosmetic and Investigational Dermatology Pub Date : 2024-08-23 eCollection Date: 2024-01-01 DOI:10.2147/CCID.S470020

Jia Deng, Yu-Jian Ye, Qiu-Ping Chen, Yi-Jin Zhang, Ji-Feng Liu

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引用次数: 0

摘要

目的：评估 HSV1 和 HSV2 抗体检测在确定生殖器疱疹感染方面的准确性：评估 HSV1 和 HSV2 抗体检测在确定生殖器疱疹感染方面的准确性：使用 ELISA 检测 HSV1 和 HSV2 IgM 和 IgG 抗体。研究比较了 HSV1 和 HSV2 抗体检测诊断生殖器疱疹的准确性：在 299 名患者中，有 14 人的 HSV1 DNA 检测呈阳性。其中 9 人有 HSV1 IgG 抗体，但没有人有 HSV2 IgG 抗体。在 278 名检测出 HSV2 DNA 的患者中，149 人的 IgG 抗体为 HSV1，9 人的 IgG 抗体为 HSV2，97 人的 IgG 抗体为 HSV1 和 HSV2。7 名患者同时具有 HSV1 和 HSV2 DNA；3 人具有 HSV1 IgG，1 人具有 HSV2 IgG，3 人同时具有这两种抗体。HSV1 IgG 检测 HSV1 感染的准确率为 64.2%，检测 HSV1 和 HSV2 合并感染的准确率为 85.7%。HSV2 IgG 检测 HSV2 感染的准确率为 38.1%，检测 HSV1 和 HSV2 合并感染的准确率为 57.1%。综合抗体阳性准确率为 34.9%：结论：生殖器疱疹主要由 HSV2（92.98%）引起。结论：生殖器疱疹主要由 HSV2（92.98%）引起，HSV1（4.67%）或合并感染（2.34%）所占比例较小。尽管抗体检测的诊断准确率相对较低（34.9%-85.7%），但仍有必要进行联合抗体检测。建议使用疱疹 DNA 检测进行准确诊断。没有抗体并不能排除生殖器疱疹的可能性，临床评估至关重要。

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Comparison of the Accuracy of HSV1 and HSV2 Antibody Tests with PCR in the Diagnosis of Recurrent Genital Herpes.

Objective: To assess the accuracy of HSV1and HSV2 antibody testing in identifying genital herpes infection.

Methods: A cohort of 299 patients previously diagnosed with recurrent genital herpes, confirmed via PCR, were tested using ELISA for HSV1 and HSV2 IgM and IgG antibodies. The study compared the accuracy of HSV1 and HSV2 antibody tests in diagnosing genital herpes.

Results: Among 299 patients, 14 tested positives for HSV1 DNA. Of these, 9 had HSV1 IgG antibodies, but none had HSV2 IgG antibody. Among 278 patients with HSV2 DNA, 149 had HSV1 IgG, 9 had HSV2 IgG, and 97 had both. Seven patients had both HSV1 and HSV2 DNA; 3 had HSV1 IgG, 1 had HSV2 IgG, and 3 had both. The accuracy of HSV1 IgG for HSV1 infection was 64.2%, and for HSV1 and HSV2 co-infection, 85.7%. The accuracy of HSV2 IgG for HSV2 infection was 38.1%, and for HSV1 and HSV2 co-infection, 57.1%. The combined antibody positivity accuracy was 34.9%.

Conclusion: Genital herpes is primarily caused by HSV2 (92.98%). A smaller percentage is HSV1 (4.67%) or co-infection (2.34%). Despite relatively low diagnostic accuracy (34.9-85.7%) for antibody detection, combined antibody testing is necessary. Herpes DNA testing is recommended for accurate diagnosis. Absence of antibodies does not rule out genital herpes and clinical assessment is essential.

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来源期刊

Clinical, Cosmetic and Investigational Dermatology Medicine-Dermatology

CiteScore

2.80

自引率

4.30%

发文量

353

审稿时长

16 weeks

期刊介绍： Clinical, Cosmetic and Investigational Dermatology is an international, peer-reviewed, open access journal that focuses on the latest clinical and experimental research in all aspects of skin disease and cosmetic interventions. Normal and pathological processes in skin development and aging, their modification and treatment, as well as basic research into histology of dermal and dermal structures that provide clinical insights and potential treatment options are key topics for the journal. Patient satisfaction, preference, quality of life, compliance, persistence and their role in developing new management options to optimize outcomes for target conditions constitute major areas of interest. The journal is characterized by the rapid reporting of clinical studies, reviews and original research in skin research and skin care. All areas of dermatology will be covered; contributions will be welcomed from all clinicians and basic science researchers globally.