{"title":"膳食中硝酸盐、亚硝酸盐和总抗氧化能力与心脏代谢风险因素的关系:一项针对 2 型糖尿病患者的横断面研究。","authors":"Laleh Karimzadeh, Vahideh Behrouz, Golbon Sohrab, Taraneh Razavion, Saiedeh Haji-Maghsoudi","doi":"10.1080/09637486.2024.2395817","DOIUrl":null,"url":null,"abstract":"<p><p>Diabetes is a common, chronic, and complex disorder that leads to several disabilities and serious complications. Certain nutrients can be effective in the management of diabetes mellitus. In the present study, we aimed to investigate the effects of dietary nitrate, nitrite, dietary total antioxidant capacity (DTAC), and nitric oxide (NO) index on some cardiometabolic parameters in patients with diabetes. This cross-sectional study was conducted on 100 participants with type 2 diabetes. A validated, semi-quantitative, food frequency questionnaire was collected to evaluate dietary intakes. Anthropometric parameters, blood pressure, and biochemical parameters, including glycemic indices, lipid profile, high-sensitive C-reactive protein (hs-CRP), and serum NO were measured using standard methods. Higher intakes of nitrate and nitrite in our study were primarily attributed to drinking water, vegetables, grains (for nitrate), dairy products, and legumes (for nitrite) rather than higher meat intakes. After adjustment for total energy, MET, BMI, and age, higher intake of nitrate was related to lower HbA1C (<i>p</i> = 0.001) and hs-CRP (<i>p</i> = 0.0.23), and greater HDL-C (<i>p</i> < 0.001) and serum NO (<i>p</i> = 0.008). Moreover, a greater nitrite intake was associated with lower DBP (<i>p</i> = 0.017), HbA1C (<i>p</i> = 0.040), FPG (<i>p</i> = 0.011), and higher serum NO values (<i>p</i> = 0.001). Higher amounts of DTAC and NO index were also related to greater DBP (<i>p</i> < 0.001, and <i>p</i> = 0.004, respectively) and lower hs-CRP (<i>p</i> = 0.004, and <i>p</i> = 0.009, respectively). High intakes of dietary nitrate and nitrite, in the context of high DTAC, are significantly associated with the improvement of some cardiometabolic parameters in patients with diabetes.</p>","PeriodicalId":14087,"journal":{"name":"International Journal of Food Sciences and Nutrition","volume":" ","pages":"695-706"},"PeriodicalIF":3.5000,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"The association between dietary nitrate, nitrite and total antioxidant capacity with cardiometabolic risk factors: a cross-sectional study among patients with type 2 diabetes.\",\"authors\":\"Laleh Karimzadeh, Vahideh Behrouz, Golbon Sohrab, Taraneh Razavion, Saiedeh Haji-Maghsoudi\",\"doi\":\"10.1080/09637486.2024.2395817\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><p>Diabetes is a common, chronic, and complex disorder that leads to several disabilities and serious complications. Certain nutrients can be effective in the management of diabetes mellitus. In the present study, we aimed to investigate the effects of dietary nitrate, nitrite, dietary total antioxidant capacity (DTAC), and nitric oxide (NO) index on some cardiometabolic parameters in patients with diabetes. This cross-sectional study was conducted on 100 participants with type 2 diabetes. A validated, semi-quantitative, food frequency questionnaire was collected to evaluate dietary intakes. Anthropometric parameters, blood pressure, and biochemical parameters, including glycemic indices, lipid profile, high-sensitive C-reactive protein (hs-CRP), and serum NO were measured using standard methods. Higher intakes of nitrate and nitrite in our study were primarily attributed to drinking water, vegetables, grains (for nitrate), dairy products, and legumes (for nitrite) rather than higher meat intakes. After adjustment for total energy, MET, BMI, and age, higher intake of nitrate was related to lower HbA1C (<i>p</i> = 0.001) and hs-CRP (<i>p</i> = 0.0.23), and greater HDL-C (<i>p</i> < 0.001) and serum NO (<i>p</i> = 0.008). Moreover, a greater nitrite intake was associated with lower DBP (<i>p</i> = 0.017), HbA1C (<i>p</i> = 0.040), FPG (<i>p</i> = 0.011), and higher serum NO values (<i>p</i> = 0.001). Higher amounts of DTAC and NO index were also related to greater DBP (<i>p</i> < 0.001, and <i>p</i> = 0.004, respectively) and lower hs-CRP (<i>p</i> = 0.004, and <i>p</i> = 0.009, respectively). High intakes of dietary nitrate and nitrite, in the context of high DTAC, are significantly associated with the improvement of some cardiometabolic parameters in patients with diabetes.</p>\",\"PeriodicalId\":14087,\"journal\":{\"name\":\"International Journal of Food Sciences and Nutrition\",\"volume\":\" \",\"pages\":\"695-706\"},\"PeriodicalIF\":3.5000,\"publicationDate\":\"2024-11-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"International Journal of Food Sciences and Nutrition\",\"FirstCategoryId\":\"97\",\"ListUrlMain\":\"https://doi.org/10.1080/09637486.2024.2395817\",\"RegionNum\":2,\"RegionCategory\":\"农林科学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"2024/8/28 0:00:00\",\"PubModel\":\"Epub\",\"JCR\":\"Q2\",\"JCRName\":\"FOOD SCIENCE & TECHNOLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"International Journal of Food Sciences and Nutrition","FirstCategoryId":"97","ListUrlMain":"https://doi.org/10.1080/09637486.2024.2395817","RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2024/8/28 0:00:00","PubModel":"Epub","JCR":"Q2","JCRName":"FOOD SCIENCE & TECHNOLOGY","Score":null,"Total":0}
引用次数: 0
摘要
糖尿病是一种常见的慢性复杂疾病,会导致多种残疾和严重并发症。某些营养素可有效控制糖尿病。在本研究中,我们旨在调查膳食硝酸盐、亚硝酸盐、膳食总抗氧化能力(DTAC)和一氧化氮(NO)指数对糖尿病患者某些心脏代谢参数的影响。这项横断面研究的对象是 100 名 2 型糖尿病患者。研究人员收集了一份经过验证的半定量食物频率问卷,以评估饮食摄入量。采用标准方法测量了人体测量参数、血压和生化参数,包括血糖指数、血脂概况、高敏C反应蛋白(hs-CRP)和血清氮氧化物。在我们的研究中,硝酸盐和亚硝酸盐摄入量较高的主要原因是饮用水、蔬菜、谷物(硝酸盐)、乳制品和豆类(亚硝酸盐),而不是肉类摄入量较高。在对总能量、MET、BMI 和年龄进行调整后,较高的硝酸盐摄入量与较低的 HbA1C(P = 0.001)和 hs-CRP (P = 0.0.23)以及较高的 HDL-C (P = 0.008)有关。此外,亚硝酸盐摄入量越高,DBP(p = 0.017)、HbA1C(p = 0.040)、FPG(p = 0.011)越低,血清 NO 值越高(p = 0.001)。较高的 DTAC 和 NO 指数也与较高的 DBP(分别为 p = 0.004)和较低的 hs-CRP(分别为 p = 0.004 和 p = 0.009)有关。在高 DTAC 的情况下,膳食中硝酸盐和亚硝酸盐的高摄入量与糖尿病患者某些心脏代谢参数的改善显著相关。
The association between dietary nitrate, nitrite and total antioxidant capacity with cardiometabolic risk factors: a cross-sectional study among patients with type 2 diabetes.
Diabetes is a common, chronic, and complex disorder that leads to several disabilities and serious complications. Certain nutrients can be effective in the management of diabetes mellitus. In the present study, we aimed to investigate the effects of dietary nitrate, nitrite, dietary total antioxidant capacity (DTAC), and nitric oxide (NO) index on some cardiometabolic parameters in patients with diabetes. This cross-sectional study was conducted on 100 participants with type 2 diabetes. A validated, semi-quantitative, food frequency questionnaire was collected to evaluate dietary intakes. Anthropometric parameters, blood pressure, and biochemical parameters, including glycemic indices, lipid profile, high-sensitive C-reactive protein (hs-CRP), and serum NO were measured using standard methods. Higher intakes of nitrate and nitrite in our study were primarily attributed to drinking water, vegetables, grains (for nitrate), dairy products, and legumes (for nitrite) rather than higher meat intakes. After adjustment for total energy, MET, BMI, and age, higher intake of nitrate was related to lower HbA1C (p = 0.001) and hs-CRP (p = 0.0.23), and greater HDL-C (p < 0.001) and serum NO (p = 0.008). Moreover, a greater nitrite intake was associated with lower DBP (p = 0.017), HbA1C (p = 0.040), FPG (p = 0.011), and higher serum NO values (p = 0.001). Higher amounts of DTAC and NO index were also related to greater DBP (p < 0.001, and p = 0.004, respectively) and lower hs-CRP (p = 0.004, and p = 0.009, respectively). High intakes of dietary nitrate and nitrite, in the context of high DTAC, are significantly associated with the improvement of some cardiometabolic parameters in patients with diabetes.
期刊介绍:
The primary aim of International Journal of Food Sciences and Nutrition is to integrate food science with nutrition. Improvement of knowledge in human nutrition should always be the final objective of submitted research. It''s an international, peer-reviewed journal which publishes high quality, original research contributions to scientific knowledge. All manuscript submissions are subject to initial appraisal by the Editor, and, if found suitable for further consideration, to peer review by independent, anonymous expert referees. All peer review is single blind and submission is online via ScholarOne Manuscripts.