能量积分探测器和光子计数探测器 CT 血管造影术心肌放射学特征的个体内再现性。

IF 3.7 Q1 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING European Radiology Experimental Pub Date : 2024-08-28 DOI:10.1186/s41747-024-00493-7
Giuseppe Tremamunno, Akos Varga-Szemes, U Joseph Schoepf, Andrea Laghi, Emese Zsarnoczay, Nicola Fink, Gilberto J Aquino, Jim O'Doherty, Tilman Emrich, Milan Vecsey-Nagy
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引用次数: 0

摘要

背景:由于放射组学易受技术因素的影响,目前尚未应用于临床实践。我们的目的是评估在能量积分探测器计算机断层扫描(EID-CT)和光子计数探测器计算机断层扫描(PCD-CT)两种系统上进行冠状动脉 CT 血管造影(CCTA)的患者的心肌放射组学特征的稳定性以及扫描间和读片机间的再现性:连续接受有临床指征的 EID-CT CCTA 检查的患者在 30 天内接受 PCD-CT CCTA 检查。为 PCD-CT 生成不同 KeV 水平的虚拟单能图像 (VMI) 和多色图像 (T3D),扫描之间的图像重建参数标准化。两名读片员进行心肌分割,并对 EID-CT 和 PDC-CT 系列的 110 个放射学特征进行单独比较。使用类内相关系数和配对 t 检验评估参数的一致性,以确定参数的稳定性:共纳入 18 名患者(15 名男性),年龄为 67.6 ± 9.7 岁(平均 ± 标准差)。除多色 PCD-CT 重建外,与 EID-CT 相比,60 和 70-keV VMI 的特征稳定性最高(分别为 96%、90% 和 92%)。即使在最有利的比较中,特征的扫描间再现性也处于中等水平(T3D 的 ICC 中位数为 0.50 [四分位间范围为 0.20-0.60];60 keV 为 0.56 [0.33-0.74];70 keV 为 0.50 [0.36-0.62])。PCD-CT系列的读片机间重现性极佳,EID-CT分割的重现性良好:结论:大多数心肌放射学特征在 EID-CT 和 PCD-CT 之间保持稳定。虽然不同扫描仪之间的特征显示出中等程度的可重复性,但 PCD-CT 相关技术的进步可能会带来更高的可重复性,从而有可能加快未来的标准化工作:虽然 PCD-CT 的使用有助于减少放射组学分析中读片机之间的差异,但在未来的研究中应考虑到与 EID-CT 相比观察到的扫描仪之间的差异,并努力将其对未来放射组学研究的影响降至最低:要点:在某些 VMIs 上,EID-CT 和 PCD-CT 的大多数心肌放射组学特征是稳定的。不同检测器技术之间参数的再现性有限。PCD-CT 提高了心肌放射学特征的读片机间再现性。
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Intraindividual reproducibility of myocardial radiomic features between energy-integrating detector and photon-counting detector CT angiography.

Background: Radiomics is not yet used in clinical practice due to concerns regarding its susceptibility to technical factors. We aimed to assess the stability and interscan and interreader reproducibility of myocardial radiomic features between energy-integrating detector computed tomography (EID-CT) and photon-counting detector CT (PCD-CT) in patients undergoing coronary CT angiography (CCTA) on both systems.

Methods: Consecutive patients undergoing clinically indicated CCTA on an EID-CT were prospectively enrolled for a PCD-CT CCTA within 30 days. Virtual monoenergetic images (VMI) at various keV levels and polychromatic images (T3D) were generated for PCD-CT, with image reconstruction parameters standardized between scans. Two readers performed myocardial segmentation and 110 radiomic features were compared intraindividually between EID-CT and PDC-CT series. The agreement of parameters was assessed using the intraclass correlation coefficient and paired t-test for the stability of the parameters.

Results: Eighteen patients (15 males) aged 67.6 ± 9.7 years (mean ± standard deviation) were included. Besides polychromatic PCD-CT reconstructions, 60- and 70-keV VMIs showed the highest feature stability compared to EID-CT (96%, 90%, and 92%, respectively). The interscan reproducibility of features was moderate even in the most favorable comparisons (median ICC 0.50 [interquartile range 0.20-0.60] for T3D; 0.56 [0.33-0.74] for 60 keV; 0.50 [0.36-0.62] for 70 keV). Interreader reproducibility was excellent for the PCD-CT series and good for EID-CT segmentations.

Conclusion: Most myocardial radiomic features remain stable between EID-CT and PCD-CT. While features demonstrated moderate reproducibility between scanners, technological advances associated with PCD-CT may lead to greater reproducibility, potentially expediting future standardization efforts.

Relevance statement: While the use of PCD-CT may facilitate reduced interreader variability in radiomics analysis, the observed interscanner variations in comparison to EID-CT should be taken into account in future research, with efforts being made to minimize their impact in future radiomics studies.

Key points: Most myocardial radiomic features resulted in being stable between EID-CT and PCD-CT on certain VMIs. The reproducibility of parameters between detector technologies was limited. PCD-CT improved interreader reproducibility of myocardial radiomic features.

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来源期刊
European Radiology Experimental
European Radiology Experimental Medicine-Radiology, Nuclear Medicine and Imaging
CiteScore
6.70
自引率
2.60%
发文量
56
审稿时长
18 weeks
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