Bio-fabrication of chitosan-coated cobalt oxide nanocomposite for enhanced bacterial inhibition and oxidative stress mitigation

This work focuses on the fabrication of chitosan-coated Co₃O₄ nanocomposite (NC) through the utilization of Cissus quadrangularis (CQ) plant extract and the assessment of its biological activities. The plant extract contains various phytoconstituents, which can serve as reducing and stabilizing agents. Moreover, the DPPH test verified the antioxidant activity and the enhanced antibacterial efficacy was tested against S. aureus and E. coli bacterial strains. The hemolysis analysis was also utilized to assess the compatibility with human RBCs. These findings have important implications in the pharmaceutical industry as a possible antioxidant and antibacterial agent.