儿童慢性腹膜透析

Iona Madden, Michelle Blaauw, Natasha Baugh, Lesley Rees, Rukshana Shroff
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引用次数: 0

摘要

终末期肾病在儿童和青少年中很少见。肾脏替代疗法(KRT)的可用性和类型差异很大,全球发病率为每百万年龄人口 18-100 例(pmarp)。慢性腹膜透析(PD)几乎普遍适用,成本效益高,而且可以在家中进行治疗,因此被认为是年幼儿童的首选透析方式。这与儿童的学业和社会生活最为协调。技术的进步甚至改善了最年幼儿童的治疗效果,但死亡率仍然很高,发病率和护理负担不容低估。透析儿童的最佳管理需要一个多学科团队,并考虑到儿童和家庭的期望。由于高质量的随机试验很少,临床医生只能依靠前瞻性队列研究和国际登记来了解和改进管理策略。接受透析的儿童将终生接受 KRT。透析方式和管理的选择必须考虑透析通路保护的原则。本综述总结了当前的流行病学、透析原则、透析通路、透析方式、处方和并发症,并简要讨论了婴儿透析及其独特的伦理和技术考虑因素。
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Chronic peritoneal dialysis in children

End stage kidney disease is rare in children and adolescents. The availability and types of kidney replacement therapy (KRT) vary widely, with a global prevalence of 18–100 per million age-related population (pmarp). Chronic peritoneal dialysis (PD) is considered the dialysis modality of choice in younger children given its almost universal applicability, cost-effectiveness, and the possibility of a home-based treatment. This is most compatible with a child's schooling and social life. Advances in technology have improved outcomes even for the youngest children, but mortality remains high, and the morbidity and burden of care should not be underestimated. Optimal management of children on dialysis requires a multidisciplinary team and consideration of the child and family's expectations. With few high-quality randomised trials, clinicians are reliant on prospective cohort studies and international registries to inform and improve management strategies. Children on dialysis have a lifetime of KRT ahead of them. The selection of dialysis modality and management must consider the principles of dialysis access preservation. This review summarises current epidemiology, principles of dialysis, PD access, modalities, prescriptions, and complications of PD, as well as a brief discussion on PD in infants with their unique ethical and technical considerations.

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来源期刊
Paediatrics and Child Health (United Kingdom)
Paediatrics and Child Health (United Kingdom) Medicine-Pediatrics, Perinatology and Child Health
CiteScore
1.20
自引率
0.00%
发文量
70
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