{"title":"端粒生物学及其在精神分裂症谱系障碍中的维持：探索与认知的联系","authors":"","doi":"10.1016/j.schres.2024.08.011","DOIUrl":null,"url":null,"abstract":"<div><h3>Objective</h3><p>Contemporary research suggests reduced telomere length in schizophrenia spectrum disorders (SZ) compared to age-adjusted non-affected individuals. However, the role of telomere maintenance and telomere repair in SZ is poorly understood as well as the involvement of telomere biology in cognitive abnormalities in SZ.</p></div><div><h3>Methods</h3><p>The study consisted of 758 participants (SZ [<em>n</em> = 357] and healthy controls, HC [<em>n</em> = 401]) collected as part of the Norwegian TOP study. Participants were assessed with standardized neuropsychological tests measuring five cognitive domains. Leucocyte telomere length (TL) was measured via blood and determined by quantitative real-time Polymerase Chain Reaction (qPCR) providing a telomere to single copy ratio (T/S ratio), used to estimate the mean telomere length. Telomerase activity was assessed by the expression levels of the Telomerase Reverse Transcriptase (<em>TERT</em>) and Telomerase RNA Component (<em>TERC</em>) genes. To assess telomere maintenance and telomere repair we calculated the telomerase expression to TL ratio (<em>TERT</em>/TL and <em>TERC</em>/TL respectively).</p></div><div><h3>Results</h3><p>Patients had reduced <em>TERT</em> (<em>F</em> = 5.03, <em>p</em> = 0.03), but not <em>TERC</em> expression (<em>F</em> = 1.04, <em>p</em> = 0.31), and higher <em>TERT</em>/TL (<em>F</em> = 6.68, <em>p</em> = 0.01) and <em>TERC</em>/TL (<em>F</em> = 6.71, <em>p</em> = 0.01), adjusted for age, sex, and ethnicity. No statistically significant association was observed between any of the telomere biology markers and the cognitive domains (<em>p</em> > 0.05).</p></div><div><h3>Conclusion</h3><p>Our study shows changes in <em>TERT</em> expression and telomere maintenance and telomere repair in SZ compared HC. However, the role of telomere biology in the mechanism underlying cognitive impairment in psychosis seems limited.</p></div>","PeriodicalId":21417,"journal":{"name":"Schizophrenia Research","volume":null,"pages":null},"PeriodicalIF":3.6000,"publicationDate":"2024-08-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S0920996424003827/pdfft?md5=1d24d26af842c38591ff5eaed298916d&pid=1-s2.0-S0920996424003827-main.pdf","citationCount":"0","resultStr":"{\"title\":\"Telomere biology and its maintenance in schizophrenia spectrum disorders: Exploring links to cognition\",\"authors\":\"\",\"doi\":\"10.1016/j.schres.2024.08.011\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><h3>Objective</h3><p>Contemporary research suggests reduced telomere length in schizophrenia spectrum disorders (SZ) compared to age-adjusted non-affected individuals. However, the role of telomere maintenance and telomere repair in SZ is poorly understood as well as the involvement of telomere biology in cognitive abnormalities in SZ.</p></div><div><h3>Methods</h3><p>The study consisted of 758 participants (SZ [<em>n</em> = 357] and healthy controls, HC [<em>n</em> = 401]) collected as part of the Norwegian TOP study. Participants were assessed with standardized neuropsychological tests measuring five cognitive domains. Leucocyte telomere length (TL) was measured via blood and determined by quantitative real-time Polymerase Chain Reaction (qPCR) providing a telomere to single copy ratio (T/S ratio), used to estimate the mean telomere length. Telomerase activity was assessed by the expression levels of the Telomerase Reverse Transcriptase (<em>TERT</em>) and Telomerase RNA Component (<em>TERC</em>) genes. To assess telomere maintenance and telomere repair we calculated the telomerase expression to TL ratio (<em>TERT</em>/TL and <em>TERC</em>/TL respectively).</p></div><div><h3>Results</h3><p>Patients had reduced <em>TERT</em> (<em>F</em> = 5.03, <em>p</em> = 0.03), but not <em>TERC</em> expression (<em>F</em> = 1.04, <em>p</em> = 0.31), and higher <em>TERT</em>/TL (<em>F</em> = 6.68, <em>p</em> = 0.01) and <em>TERC</em>/TL (<em>F</em> = 6.71, <em>p</em> = 0.01), adjusted for age, sex, and ethnicity. No statistically significant association was observed between any of the telomere biology markers and the cognitive domains (<em>p</em> > 0.05).</p></div><div><h3>Conclusion</h3><p>Our study shows changes in <em>TERT</em> expression and telomere maintenance and telomere repair in SZ compared HC. However, the role of telomere biology in the mechanism underlying cognitive impairment in psychosis seems limited.</p></div>\",\"PeriodicalId\":21417,\"journal\":{\"name\":\"Schizophrenia Research\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":3.6000,\"publicationDate\":\"2024-08-28\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.sciencedirect.com/science/article/pii/S0920996424003827/pdfft?md5=1d24d26af842c38591ff5eaed298916d&pid=1-s2.0-S0920996424003827-main.pdf\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Schizophrenia Research\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S0920996424003827\",\"RegionNum\":2,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q1\",\"JCRName\":\"PSYCHIATRY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Schizophrenia Research","FirstCategoryId":"3","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S0920996424003827","RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"PSYCHIATRY","Score":null,"Total":0}
Telomere biology and its maintenance in schizophrenia spectrum disorders: Exploring links to cognition
Objective
Contemporary research suggests reduced telomere length in schizophrenia spectrum disorders (SZ) compared to age-adjusted non-affected individuals. However, the role of telomere maintenance and telomere repair in SZ is poorly understood as well as the involvement of telomere biology in cognitive abnormalities in SZ.
Methods
The study consisted of 758 participants (SZ [n = 357] and healthy controls, HC [n = 401]) collected as part of the Norwegian TOP study. Participants were assessed with standardized neuropsychological tests measuring five cognitive domains. Leucocyte telomere length (TL) was measured via blood and determined by quantitative real-time Polymerase Chain Reaction (qPCR) providing a telomere to single copy ratio (T/S ratio), used to estimate the mean telomere length. Telomerase activity was assessed by the expression levels of the Telomerase Reverse Transcriptase (TERT) and Telomerase RNA Component (TERC) genes. To assess telomere maintenance and telomere repair we calculated the telomerase expression to TL ratio (TERT/TL and TERC/TL respectively).
Results
Patients had reduced TERT (F = 5.03, p = 0.03), but not TERC expression (F = 1.04, p = 0.31), and higher TERT/TL (F = 6.68, p = 0.01) and TERC/TL (F = 6.71, p = 0.01), adjusted for age, sex, and ethnicity. No statistically significant association was observed between any of the telomere biology markers and the cognitive domains (p > 0.05).
Conclusion
Our study shows changes in TERT expression and telomere maintenance and telomere repair in SZ compared HC. However, the role of telomere biology in the mechanism underlying cognitive impairment in psychosis seems limited.
期刊介绍：
As official journal of the Schizophrenia International Research Society (SIRS) Schizophrenia Research is THE journal of choice for international researchers and clinicians to share their work with the global schizophrenia research community. More than 6000 institutes have online or print (or both) access to this journal - the largest specialist journal in the field, with the largest readership!
Schizophrenia Research''s time to first decision is as fast as 6 weeks and its publishing speed is as fast as 4 weeks until online publication (corrected proof/Article in Press) after acceptance and 14 weeks from acceptance until publication in a printed issue.
The journal publishes novel papers that really contribute to understanding the biology and treatment of schizophrenic disorders; Schizophrenia Research brings together biological, clinical and psychological research in order to stimulate the synthesis of findings from all disciplines involved in improving patient outcomes in schizophrenia.
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