Saba Shahrivari-Baviloliaei, Ilkay Erdogan Orhan, Nurten Abaci Kaplan, Agnieszka Konopacka, Krzysztof Waleron, Alina Plenis, Agnieszka Viapiana
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Moreover, the highest antioxidant activity in DPPH, FRAP, ABTS, and CUPRAC assays was found in the sample containing the roots in loose form from USA. <i>A. membranaceus</i> extracts displayed the inhibition zone diameters within the range from 10 to 22 mm antimicrobial activity against <i>S. aureus</i>, while there were no inhibition zones in any extracts in case of <i>E. coli</i>. The extracts of <i>A. membranaceous</i> showed an inhibition rate below 40% against TYR, and among tested extracts, only two samples were able to inhibit BChE with IC<sub>50</sub> values of above 30 µg/mL. Correlation analysis showed a highly positive relationship between their phenolic composition and antioxidant activity. Concluding, the obtained results confirmed that <i>A. membranaceus</i> commercial samples could be an important dietary source of natural antioxidants.</p>","PeriodicalId":7984,"journal":{"name":"Antioxidants","volume":null,"pages":null},"PeriodicalIF":6.0000,"publicationDate":"2024-08-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11351125/pdf/","citationCount":"0","resultStr":"{\"title\":\"Characterization of Phenolic Profile and Biological Properties of <i>Astragalus membranaceus</i> Fisch. ex Bunge Commercial Samples.\",\"authors\":\"Saba Shahrivari-Baviloliaei, Ilkay Erdogan Orhan, Nurten Abaci Kaplan, Agnieszka Konopacka, Krzysztof Waleron, Alina Plenis, Agnieszka Viapiana\",\"doi\":\"10.3390/antiox13080993\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><p><i>Astragalus membranaceus</i> Fisch. ex Bunge (syn. <i>Astragalus mongholicus</i> Bunge) is one of the notable medicinal and food plants. Therefore, the aim of this study was to calculate the phenolic composition and antioxidant, antimicrobial, as well as enzyme inhibitory [acetylcholinesterase (AChE), butyrylcholinesterase (BChE), and tyrosinase (TYR)] activities with chemometric approaches of the hydromethanolic and water extracts of commercial <i>A. membranaceus</i> samples. Ten individual phenolic compounds were determined using high-performance liquid chromatography (HPLC), and only quercetin was found at a level of above 80 µg/g DW in both extracts. Moreover, the highest antioxidant activity in DPPH, FRAP, ABTS, and CUPRAC assays was found in the sample containing the roots in loose form from USA. <i>A. membranaceus</i> extracts displayed the inhibition zone diameters within the range from 10 to 22 mm antimicrobial activity against <i>S. aureus</i>, while there were no inhibition zones in any extracts in case of <i>E. coli</i>. The extracts of <i>A. membranaceous</i> showed an inhibition rate below 40% against TYR, and among tested extracts, only two samples were able to inhibit BChE with IC<sub>50</sub> values of above 30 µg/mL. Correlation analysis showed a highly positive relationship between their phenolic composition and antioxidant activity. 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Characterization of Phenolic Profile and Biological Properties of Astragalus membranaceus Fisch. ex Bunge Commercial Samples.
Astragalus membranaceus Fisch. ex Bunge (syn. Astragalus mongholicus Bunge) is one of the notable medicinal and food plants. Therefore, the aim of this study was to calculate the phenolic composition and antioxidant, antimicrobial, as well as enzyme inhibitory [acetylcholinesterase (AChE), butyrylcholinesterase (BChE), and tyrosinase (TYR)] activities with chemometric approaches of the hydromethanolic and water extracts of commercial A. membranaceus samples. Ten individual phenolic compounds were determined using high-performance liquid chromatography (HPLC), and only quercetin was found at a level of above 80 µg/g DW in both extracts. Moreover, the highest antioxidant activity in DPPH, FRAP, ABTS, and CUPRAC assays was found in the sample containing the roots in loose form from USA. A. membranaceus extracts displayed the inhibition zone diameters within the range from 10 to 22 mm antimicrobial activity against S. aureus, while there were no inhibition zones in any extracts in case of E. coli. The extracts of A. membranaceous showed an inhibition rate below 40% against TYR, and among tested extracts, only two samples were able to inhibit BChE with IC50 values of above 30 µg/mL. Correlation analysis showed a highly positive relationship between their phenolic composition and antioxidant activity. Concluding, the obtained results confirmed that A. membranaceus commercial samples could be an important dietary source of natural antioxidants.
AntioxidantsBiochemistry, Genetics and Molecular Biology-Physiology
CiteScore
10.60
自引率
11.40%
发文量
2123
审稿时长
16.3 days
期刊介绍：
Antioxidants (ISSN 2076-3921), provides an advanced forum for studies related to the science and technology of antioxidants. It publishes research papers, reviews and communications. Our aim is to encourage scientists to publish their experimental and theoretical results in as much detail as possible. There is no restriction on the length of the papers. The full experimental details must be provided so that the results can be reproduced. Electronic files and software regarding the full details of the calculation or experimental procedure, if unable to be published in a normal way, can be deposited as supplementary electronic material.
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