细胞内免疫学的新范例:线粒体成为主要的免疫细胞器

IF 10.7 1区 生物学 Q1 BIOCHEMISTRY & MOLECULAR BIOLOGY Redox Biology Pub Date : 2024-08-29 DOI:10.1016/j.redox.2024.103331
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引用次数: 0

摘要

线粒体因其在能量生产中的关键作用而被公认为细胞的 "动力室",如今,它已成为生物能、代谢信号和免疫交叉点上的多功能细胞器。然而,人们对它们对免疫和炎症的确切贡献的认识仍在发展之中。这篇综述首先介绍了细胞内免疫这一创新概念,强调线粒体如何充当关键的免疫信号枢纽。线粒体在识别和响应病原体和危险信号以及调节免疫反应方面发挥着重要作用。我们还提出线粒体是主要的免疫细胞器,在抗原呈递、免疫调节和免疫反应功能方面与更广泛的免疫系统相似。我们的综合综述探讨了线粒体免疫信号通路及其在控制炎症和慢性疾病方面的治疗潜力,并讨论了线粒体研究的前沿方法。这篇综述面向线粒体功能专家和该领域新手的广大读者,提出了可能改变我们对细胞内免疫和细胞内细胞器综合免疫功能的理解的新方向。
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A new paradigm in intracellular immunology: Mitochondria emerging as leading immune organelles

Mitochondria, traditionally recognized as cellular 'powerhouses' due to their pivotal role in energy production, have emerged as multifunctional organelles at the intersection of bioenergetics, metabolic signaling, and immunity. However, the understanding of their exact contributions to immunity and inflammation is still developing. This review first introduces the innovative concept of intracellular immunity, emphasizing how mitochondria serve as critical immune signaling hubs. They are instrumental in recognizing and responding to pathogen and danger signals, and in modulating immune responses. We also propose mitochondria as the leading immune organelles, drawing parallels with the broader immune system in their functions of antigen presentation, immune regulation, and immune response. Our comprehensive review explores mitochondrial immune signaling pathways, their therapeutic potential in managing inflammation and chronic diseases, and discusses cutting-edge methodologies for mitochondrial research. Targeting a broad readership of both experts in mitochondrial functions and newcomers to the field, this review sets forth new directions that could transform our understanding of intracellular immunity and the integrated immune functions of intracellular organelles.

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来源期刊
Redox Biology
Redox Biology BIOCHEMISTRY & MOLECULAR BIOLOGY-
CiteScore
19.90
自引率
3.50%
发文量
318
审稿时长
25 days
期刊介绍: Redox Biology is the official journal of the Society for Redox Biology and Medicine and the Society for Free Radical Research-Europe. It is also affiliated with the International Society for Free Radical Research (SFRRI). This journal serves as a platform for publishing pioneering research, innovative methods, and comprehensive review articles in the field of redox biology, encompassing both health and disease. Redox Biology welcomes various forms of contributions, including research articles (short or full communications), methods, mini-reviews, and commentaries. Through its diverse range of published content, Redox Biology aims to foster advancements and insights in the understanding of redox biology and its implications.
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