基于血浆代谢组分析探索结节性瘙痒症的潜在生物标记物

IF 3.5 3区 医学 Q1 DERMATOLOGY Experimental Dermatology Pub Date : 2024-08-29 DOI:10.1111/exd.15170
Duoqin Wang, Lisi Peng, Yiqi Zhu, Shuwen Xu, Zijing Xiao, Yanyun Shen, Taiyu Jin, Yixin Shao, Hui Tang
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引用次数: 0

摘要

结节性瘙痒症(PN)是一种慢性皮肤病,会使人衰弱、严重瘙痒,对患者的生活质量和精神状态造成负面影响。然而,PN 的治疗方案仍然有限。全局代谢组学分析可提供有关能量代谢、发病机制和潜在诊断生物标志物的有效信息。目前还没有关于 PN 代谢组学分析的研究报道。为了进一步了解 PN 的发病机制并分析 PN 患者的血浆代谢物谱。我们使用液相色谱-串联质谱仪对 18 名 PN 患者和 19 名健康对照者血浆中的 306 种代谢物进行了靶向代谢组分析。我们发现了 31 种不同的代谢物。在这些代谢物中,大多数酰基肉碱、长链脂肪酸、α-氨基丁酸、羟基丁酸和乳酸在 PN 患者体内上调;相反,葡萄糖酸、亚伯酸、胆汁酸衍生物和大多数氨基酸则下调。葡萄糖二酸与瘙痒严重程度、酰基肉碱与失眠之间存在正相关。辛二酸与研究者总体评估(IGA)得分呈负相关。代谢物的变化反映了 PN 能量代谢失调和慢性系统性炎症。作为 PN 疾病严重程度的潜在生物标志物,葡萄糖酸、亚伯酸和酰基肉碱等几种代谢物值得进一步研究。
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Exploration of potential biomarkers for prurigo nodularis based on plasma-metabolome analysis

Prurigo nodularis (PN) is a chronic and debilitating skin disease with severe itching that negatively impacts patients' quality of life and mental state. However, the treatment options for PN remain limited. Global metabolomics analysis can offer effective information on energy metabolism, pathogenesis and potential diagnostic biomarkers. No study on metabolomic analysis of PN has been reported. To further understand the mechanisms of PN and analyse the plasma metabolite profiles in patients with PN. Targeted-metabolome analysis of 306 metabolites in plasma from 18 patients with PN and 19 healthy controls was performed using Liquid Chromatography-tandem Mass Spectrometer analysis. We identified 31 differential metabolites. Most acylcarnitines, long-chain fatty acids, alpha-aminobutyric acid, hydroxybutyric acid and lactic acid among these metabolites were up-regulated in patients with PN; in contrast, glucaric acid, suberic acid, bile acid derivatives and most amino acids were down-regulated. Positive correlations exist between glucaric acid and itching severity and acylcarnitines and insomnia. Suberic acid and the Investigator's Global Assessment (IGA) scores correlate negatively. Metabolite variation reflects the dysregulation of energy metabolism and chronic systematic inflammation in PN. Several metabolites, such as glucaric acid, suberic acid and acylcarnitines, merit further study as potential biomarkers of disease severity in PN.

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来源期刊
Experimental Dermatology
Experimental Dermatology 医学-皮肤病学
CiteScore
6.70
自引率
5.60%
发文量
201
审稿时长
2 months
期刊介绍: Experimental Dermatology provides a vehicle for the rapid publication of innovative and definitive reports, letters to the editor and review articles covering all aspects of experimental dermatology. Preference is given to papers of immediate importance to other investigators, either by virtue of their new methodology, experimental data or new ideas. The essential criteria for publication are clarity, experimental soundness and novelty. Letters to the editor related to published reports may also be accepted, provided that they are short and scientifically relevant to the reports mentioned, in order to provide a continuing forum for discussion. Review articles represent a state-of-the-art overview and are invited by the editors.
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