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IF 3.7 3区生物学 Q2 BIOCHEMISTRY & MOLECULAR BIOLOGY IUBMB Life Pub Date : 2024-08-30 DOI:10.1002/iub.2752

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引用次数: 0

摘要

封面：ROS 在恶性转化过程中的重要作用。ROS 清除剂（如 NRF2 和 NADPH (PPP)）在正常细胞中具有细胞抑制作用。p53 和癌基因的缺失会导致产生更多的 ROS，从而产生细胞毒性作用。在血管生成过程中，较高的 ROS 水平会影响 NADPH、AMPK 和 NRF2，从而维持细胞的存活。相反，缺氧和低血糖等 ROS 生成器会导致细胞在产生极少量 ROS 的情况下死亡。在侵袭和转移阶段，较高的 ROS 水平会通过下调 IDH1 和 NADPH 促进细胞存活。通过缺氧和低基质附着产生的较低 ROS 有利于细胞死亡，作者：Panda 等；文章首次发表于：2024 年 4 月 10 日；https://doi.org/10.1002/iub.2821.

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On the Cover: Imperative role of ROS during malignant transformation. ROS scavengers such as NRF2 and NADPH (PPP) exhibit cytostatic effects in normal cells. Loss of p53 and oncogenes elicits higher ROS production, leading to a cytotoxic effect. During angiogenesis, a higher ROS level sustains cell survival by affecting the NADPH, AMPK, and NRF2. In contrast, ROS generators such as hypoxia and low glucose levels lead to cell death at a minimal ROS generation. At the stage of invasion and metastasis, a higher ROS level facilitates cell survival via the downregulation of IDH1 and NADPH. The lower ROS generation via hypoxia and low matrix attachment facilitates cell death by Panda et al.; Article first published: 10 Apr 2024; https://doi.org/10.1002/iub.2821.

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来源期刊

IUBMB Life 生物-生化与分子生物学

CiteScore

10.60

自引率

0.00%

发文量

109

审稿时长

4-8 weeks

期刊介绍： IUBMB Life is the flagship journal of the International Union of Biochemistry and Molecular Biology and is devoted to the rapid publication of the most novel and significant original research articles, reviews, and hypotheses in the broadly defined fields of biochemistry, molecular biology, cell biology, and molecular medicine.