白藜芦醇可改善大鼠不育症

IF 5.9 3区 农林科学 Q1 VETERINARY SCIENCES Lab Animal Pub Date : 2024-08-30 DOI:10.1038/s41684-024-01434-y
Jorge Ferreira
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引用次数: 0

摘要

多项研究表明,接触阿特拉津(一种常用于玉米等旱作物的除草剂)会对生殖系统和内分泌系统产生负面影响。白藜芦醇是一种天然植物雌激素抗氧化剂,被认为是预防衰老和生殖系统损伤的有效疗法。科学报告》上的一项研究探讨了白藜芦醇能否逆转阿特拉津对雄性大鼠生殖系统造成的损害。接触阿特拉津会降低雄性大鼠的生育能力和血清睾酮水平,但与白藜芦醇共用可恢复睾酮水平。此外,虽然阿特拉津会上调 caspase 3 和 iNOS 的水平,但与只接触阿特拉津的组相比,与白藜芦醇共同处理会下调这些标记物的水平。共处理还减轻了阿特拉津对睾丸组织造成的改变。然而,白藜芦醇处理并不能挽救精子形态损伤。虽然经白藜芦醇处理的动物并没有完全摆脱阿特拉津的所有有害影响,但这项研究表明,白藜芦醇是一种潜在的有益补充剂,可保护生殖系统免受毒性影响:Hassanin, H.M., Kamal, A.A. & Ismail, O.I. 科学报告 14, 17743 (2024)
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来源期刊
Lab Animal
Lab Animal 农林科学-兽医学
CiteScore
0.60
自引率
2.90%
发文量
181
审稿时长
>36 weeks
期刊介绍: LabAnimal is a Nature Research journal dedicated to in vivo science and technology that improves our basic understanding and use of model organisms of human health and disease. In addition to basic research, methods and technologies, LabAnimal also covers important news, business and regulatory matters that impact the development and application of model organisms for preclinical research. LabAnimal's focus is on innovative in vivo methods, research and technology covering a wide range of model organisms. Our broad scope ensures that the work we publish reaches the widest possible audience. LabAnimal provides a rigorous and fair peer review of manuscripts, high standards for copyediting and production, and efficient publication.
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