{"title":"结合空间代谢组学和蛋白质组学对单细胞进行特征分析","authors":"Mayar Allam, Ahmet F. Coskun","doi":"10.1038/s41577-024-01084-8","DOIUrl":null,"url":null,"abstract":"In this Tools of the Trade article, Mayar Allam and Ahmet Coskun describe how they combined spatial metabolomics and proteomics profiling — in a framework they call scSpaMet — to explore, at the single-cell level, how metabolic profiles vary by location and in disease.","PeriodicalId":19049,"journal":{"name":"Nature Reviews Immunology","volume":" ","pages":"701-701"},"PeriodicalIF":67.7000,"publicationDate":"2024-08-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Combining spatial metabolomics and proteomics profiling of single cells\",\"authors\":\"Mayar Allam, Ahmet F. Coskun\",\"doi\":\"10.1038/s41577-024-01084-8\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"In this Tools of the Trade article, Mayar Allam and Ahmet Coskun describe how they combined spatial metabolomics and proteomics profiling — in a framework they call scSpaMet — to explore, at the single-cell level, how metabolic profiles vary by location and in disease.\",\"PeriodicalId\":19049,\"journal\":{\"name\":\"Nature Reviews Immunology\",\"volume\":\" \",\"pages\":\"701-701\"},\"PeriodicalIF\":67.7000,\"publicationDate\":\"2024-08-30\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Nature Reviews Immunology\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://www.nature.com/articles/s41577-024-01084-8\",\"RegionNum\":1,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q1\",\"JCRName\":\"IMMUNOLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Nature Reviews Immunology","FirstCategoryId":"3","ListUrlMain":"https://www.nature.com/articles/s41577-024-01084-8","RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"IMMUNOLOGY","Score":null,"Total":0}
引用次数: 0
摘要
在这篇《贸易工具》（Tools of the Trade）文章中，马亚尔-阿拉姆（Mayar Allam）和艾哈迈德-科斯昆（Ahmet Coskun）介绍了他们如何将空间代谢组学和蛋白质组学分析结合起来，在他们称之为 scSpaMet 的框架内，在单细胞水平上探索代谢特征如何因位置和疾病而异。
Combining spatial metabolomics and proteomics profiling of single cells
In this Tools of the Trade article, Mayar Allam and Ahmet Coskun describe how they combined spatial metabolomics and proteomics profiling — in a framework they call scSpaMet — to explore, at the single-cell level, how metabolic profiles vary by location and in disease.
期刊介绍：
Nature Reviews Immunology is a journal that provides comprehensive coverage of all areas of immunology, including fundamental mechanisms and applied aspects. It has two international standard serial numbers (ISSN): 1474-1733 for print and 1474-1741 for online. In addition to review articles, the journal also features recent developments and new primary papers in the field, as well as reflections on influential people, papers, and events in the development of immunology. The subjects covered by Nature Reviews Immunology include allergy and asthma, autoimmunity, antigen processing and presentation, apoptosis and cell death, chemokines and chemokine receptors, cytokines and cytokine receptors, development and function of cells of the immune system, haematopoiesis, infection and immunity, immunotherapy, innate immunity, mucosal immunology and the microbiota, regulation of the immune response, signalling in the immune system, transplantation, tumour immunology and immunotherapy, and vaccine development.
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