在一个范围不断扩大的种群中,尽管基因流动频繁,但仍能实现遗传适应。

IF 4.5 1区 生物学 Q1 BIOCHEMISTRY & MOLECULAR BIOLOGY Molecular Ecology Pub Date : 2024-08-31 DOI:10.1111/mec.17511
Andy Lee, Benjamin N Daniels, William Hemstrom, Cataixa López, Yuki Kagaya, Daisuke Kihara, Jean M Davidson, Robert J Toonen, Crow White, Mark R Christie
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引用次数: 0

摘要

在高基因流系统中,自然选择的信号可能会被迅速削弱,从而影响人们对海洋中遗传适应发生的方式和时间的理解。这个生态学和进化论中长期悬而未决的课题重新变得重要起来,因为不断变化的环境条件正推动着范围的扩大,而这种扩大可能需要快速的进化反应。其中一个例子是凯氏乳螺(Kelletia kelletii),这是一种常见的潮下腹足类动物,其浮游幼虫存活期约为 40-60 天,在 20 世纪 70 年代其生物地理范围向北扩展了 300 多公里。为了测试遗传适应性,我们用从其历史分布区(HxH)和最近扩大的分布区(ExE)采集的凯氏螺成虫进行了一系列实验杂交,并对在普通花园环境中饲养的后代进行了 RNA-Seq 分析。我们在 54 个后代样本中发现了 2770 个差异表达基因(DEGs),这些后代的祖先要么只有历史分布区(HxH 后代),要么只有扩大分布区(ExE 后代)。利用直接从 DEGs 中调用的 SNPs,我们以前所未有的准确率(HxH 后代和 ExE 后代的准确率分别为 92.6% 和 94.5%)将已知起源的样本分配回其起源地。预测重要性最高的 SNP 位于三糖磷酸异构酶(TPI)上,这是一种参与冷应激反应的重要代谢酶。TPI明显上调,并含有一个扩大范围的非同义突变。我们的研究结果表明,实验转录组学可以揭示海洋生物如何应对不断变化的环境条件的机制,从而为准确识别海洋中的扩散、基因流和种群连接模式铺平了道路。
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Genetic adaptation despite high gene flow in a range-expanding population.

Signals of natural selection can be quickly eroded in high gene flow systems, curtailing efforts to understand how and when genetic adaptation occurs in the ocean. This long-standing, unresolved topic in ecology and evolution has renewed importance because changing environmental conditions are driving range expansions that may necessitate rapid evolutionary responses. One example occurs in Kellet's whelk (Kelletia kelletii), a common subtidal gastropod with an ~40- to 60-day pelagic larval duration that expanded their biogeographic range northwards in the 1970s by over 300 km. To test for genetic adaptation, we performed a series of experimental crosses with Kellet's whelk adults collected from their historical (HxH) and recently expanded range (ExE), and conducted RNA-Seq on offspring that we reared in a common garden environment. We identified 2770 differentially expressed genes (DEGs) between 54 offspring samples with either only historical range (HxH offspring) or expanded range (ExE offspring) ancestry. Using SNPs called directly from the DEGs, we assigned samples of known origin back to their range of origin with unprecedented accuracy for a marine species (92.6% and 94.5% for HxH and ExE offspring, respectively). The SNP with the highest predictive importance occurred on triosephosphate isomerase (TPI), an essential metabolic enzyme involved in cold stress response. TPI was significantly upregulated and contained a non-synonymous mutation in the expanded range. Our findings pave the way for accurately identifying patterns of dispersal, gene flow and population connectivity in the ocean by demonstrating that experimental transcriptomics can reveal mechanisms for how marine organisms respond to changing environmental conditions.

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来源期刊
Molecular Ecology
Molecular Ecology 生物-进化生物学
CiteScore
8.40
自引率
10.20%
发文量
472
审稿时长
1 months
期刊介绍: Molecular Ecology publishes papers that utilize molecular genetic techniques to address consequential questions in ecology, evolution, behaviour and conservation. Studies may employ neutral markers for inference about ecological and evolutionary processes or examine ecologically important genes and their products directly. We discourage papers that are primarily descriptive and are relevant only to the taxon being studied. Papers reporting on molecular marker development, molecular diagnostics, barcoding, or DNA taxonomy, or technical methods should be re-directed to our sister journal, Molecular Ecology Resources. Likewise, papers with a strongly applied focus should be submitted to Evolutionary Applications. Research areas of interest to Molecular Ecology include: * population structure and phylogeography * reproductive strategies * relatedness and kin selection * sex allocation * population genetic theory * analytical methods development * conservation genetics * speciation genetics * microbial biodiversity * evolutionary dynamics of QTLs * ecological interactions * molecular adaptation and environmental genomics * impact of genetically modified organisms
期刊最新文献
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