Riho Nakajima, Masashi Kinoshita, Hirokazu Okita, Mitsutoshi Nakada
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All patients completed the assessment of QOL and various neurological and neurocognitive functions including general cognitive function, processing speed, attention, memory, emotion recognition, social cognition, visuospatial cognition, verbal fluency, language, motor function, sensation, and visual field at 6 months postoperatively. QOL was assessed using the 36-Item Short Form Survey (SF-36). In the SF-36, the physical, mental, and role and social component summary (PCS, MCS, and RCS, respectively) scores were calculated. Multiple logistic regression analyses and chi-square tests were used to evaluate the association between SF-36 scores and neurocognitive functions.</p><p><strong>Results: </strong>The MCS was maintained, while the PCS and RCS scores were significantly lower in patients with GBMs than in healthy controls (p = 0.0040 and p < 0.0001, respectively). Among several neurocognitive functions, motor function and processing speed were significantly correlated with PCS and RCS scores, respectively (p = 0.0048 and p = 0.030, respectively). Patients who maintained their RCS or PCS scores had a higher probability of preserving motor function or processing speed than those with low RCS or PCS scores (p = 0.0026).</p><p><strong>Conclusions: </strong>Motor function and processing speed may be predictors of QOL in patients with GBMs.</p>","PeriodicalId":7370,"journal":{"name":"Acta Neurochirurgica","volume":null,"pages":null},"PeriodicalIF":1.9000,"publicationDate":"2024-08-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11365834/pdf/","citationCount":"0","resultStr":"{\"title\":\"Postsurgical motor function and processing speed as predictors of quality of life in patients with chronic-phase glioblastoma.\",\"authors\":\"Riho Nakajima, Masashi Kinoshita, Hirokazu Okita, Mitsutoshi Nakada\",\"doi\":\"10.1007/s00701-024-06245-1\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Purpose: </strong>Patients with glioblastomas (GBMs) have poor prognosis despite various treatments; therefore, attention should be paid to maintaining the quality of survival. 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引用次数: 0
摘要
目的:尽管采用了多种治疗方法,但胶质母细胞瘤(GBM)患者的预后较差;因此,应注意维持患者的生存质量。神经认知功能障碍会影响 GBM 患者的生活质量(QOL)。大多数有关 QOL 和神经认知功能的研究都表明,QOL 与自我报告的神经认知功能衰退之间存在关系,尽管这种方法并不能准确反映受损的功能领域。因此,本研究旨在通过对神经认知功能的客观评估,明确影响 GBM 患者 QOL 的神经认知功能:方法:分析了 40 名新诊断为 GBMs 患者的数据。所有患者均在术后 6 个月完成了 QOL 以及各种神经和神经认知功能的评估,包括一般认知功能、处理速度、注意力、记忆力、情绪识别、社会认知、视觉空间认知、语言流畅性、语言、运动功能、感觉和视野。QOL 采用 36 项简表调查(SF-36)进行评估。在 SF-36 中,分别计算了身体、精神、角色和社交部分的总分(PCS、MCS 和 RCS)。多重逻辑回归分析和卡方检验用于评估 SF-36 评分与神经认知功能之间的关联:结果:GBMs 患者的 MCS 保持不变,而 PCS 和 RCS 分数则明显低于健康对照组(p = 0.0040 和 p 结论:GBMs 患者的运动功能和处理速度可预测其神经认知功能:运动功能和处理速度可能是预测 GBM 患者 QOL 的指标。
Postsurgical motor function and processing speed as predictors of quality of life in patients with chronic-phase glioblastoma.
Purpose: Patients with glioblastomas (GBMs) have poor prognosis despite various treatments; therefore, attention should be paid to maintaining the quality of survival. Neurocognitive deficits can affect the quality of life (QOL) in patients with GBM. Most studies concerning QOL and neurocognitive functions have demonstrated a relationship between QOL and self-reported neurocognitive decline, although this method does not accurately reflect damaged functional domains. Therefore, this study aimed to clarify the neurocognitive functions that influence the QOL in patients with GBMs using an objective assessment of neurocognitive functions.
Methods: Data from 40 patients newly diagnosed with GBMs were analyzed. All patients completed the assessment of QOL and various neurological and neurocognitive functions including general cognitive function, processing speed, attention, memory, emotion recognition, social cognition, visuospatial cognition, verbal fluency, language, motor function, sensation, and visual field at 6 months postoperatively. QOL was assessed using the 36-Item Short Form Survey (SF-36). In the SF-36, the physical, mental, and role and social component summary (PCS, MCS, and RCS, respectively) scores were calculated. Multiple logistic regression analyses and chi-square tests were used to evaluate the association between SF-36 scores and neurocognitive functions.
Results: The MCS was maintained, while the PCS and RCS scores were significantly lower in patients with GBMs than in healthy controls (p = 0.0040 and p < 0.0001, respectively). Among several neurocognitive functions, motor function and processing speed were significantly correlated with PCS and RCS scores, respectively (p = 0.0048 and p = 0.030, respectively). Patients who maintained their RCS or PCS scores had a higher probability of preserving motor function or processing speed than those with low RCS or PCS scores (p = 0.0026).
Conclusions: Motor function and processing speed may be predictors of QOL in patients with GBMs.
期刊介绍:
The journal "Acta Neurochirurgica" publishes only original papers useful both to research and clinical work. Papers should deal with clinical neurosurgery - diagnosis and diagnostic techniques, operative surgery and results, postoperative treatment - or with research work in neuroscience if the underlying questions or the results are of neurosurgical interest. Reports on congresses are given in brief accounts. As official organ of the European Association of Neurosurgical Societies the journal publishes all announcements of the E.A.N.S. and reports on the activities of its member societies. Only contributions written in English will be accepted.