18F-Fluoromisonidazole (18F-FMISO)放射性药物在血管化实体瘤中运输的数学建模。

IF 1.3 Q3 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING Biomedical Physics & Engineering Express Pub Date : 2024-09-12 DOI:10.1088/2057-1976/ad7592
Mohammad Amin Abazari, M Soltani, Faezeh Eydi, Arman Rahmim, Farshad Moradi Kashkooli
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引用次数: 0

摘要

18F-Fluoromisonidazole (18F-FMISO) 是一种极具潜力的正电子发射断层扫描放射性药物,可用于识别实体肿瘤中的缺氧区域。这项研究采用时空多尺度数学模型来探索不同程度的血管生成如何影响放射性药物在肿瘤内的传输。在这项研究中,采用了两种具有异质和均匀分布的毛细血管网络的肿瘤几何图形,以纳入不同程度的微血管密度。通过模拟血管生成过程,生成了异质血管化肿瘤的合成图像。所提出的多尺度时空模型考虑了肿瘤微环境中错综复杂的生理和生化因素,如放射性药物的跨血管传输、通过扩散和对流机制进入间质空间以及最终被肿瘤细胞吸收。结果显示,在肿瘤生长的不同阶段,18F-FMISO 吸收的定量和半定量指标在空间和时间上都有所不同。均匀血管化肿瘤中存在高微血管密度会增加细胞摄取,因为它能使放射性药物分子更有效地释放和快速分布。因此,与异质血管化肿瘤相比,细胞摄取率会更高。在肿瘤微血管异质分布和均匀分布的情况下,扩散运输机制比对流机制更为明显。本研究的发现揭示了 18F-FMISO 放射性药物在肿瘤微环境中分布和递送背后的传输现象,为肿瘤学家的常规决策过程提供了帮助。
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Mathematical modeling of18F-Fluoromisonidazole (18F-FMISO) radiopharmaceutical transport in vascularized solid tumors.

18F-Fluoromisonidazole (18F-FMISO) is a highly promising positron emission tomography radiopharmaceutical for identifying hypoxic regions in solid tumors. This research employs spatiotemporal multi-scale mathematical modeling to explore how different levels of angiogenesis influence the transport of radiopharmaceuticals within tumors. In this study, two tumor geometries with heterogeneous and uniform distributions of capillary networks were employed to incorporate varying degrees of microvascular density. The synthetic image of the heterogeneous and vascularized tumor was generated by simulating the angiogenesis process. The proposed multi-scale spatiotemporal model accounts for intricate physiological and biochemical factors within the tumor microenvironment, such as the transvascular transport of the radiopharmaceutical agent, its movement into the interstitial space by diffusion and convection mechanisms, and ultimately its uptake by tumor cells. Results showed that both quantitative and semi-quantitative metrics of18F-FMISO uptake differ spatially and temporally at different stages during tumor growth. The presence of a high microvascular density in uniformly vascularized tumor increases cellular uptake, as it allows for more efficient release and rapid distribution of radiopharmaceutical molecules. This results in enhanced uptake compared to the heterogeneous vascularized tumor. In both heterogeneous and uniform distribution of microvessels in tumors, the diffusion transport mechanism has a more pronounced than convection. The findings of this study shed light on the transport phenomena behind18F-FMISO radiopharmaceutical distribution and its delivery in the tumor microenvironment, aiding oncologists in their routine decision-making processes.

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来源期刊
Biomedical Physics & Engineering Express
Biomedical Physics & Engineering Express RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING-
CiteScore
2.80
自引率
0.00%
发文量
153
期刊介绍: BPEX is an inclusive, international, multidisciplinary journal devoted to publishing new research on any application of physics and/or engineering in medicine and/or biology. Characterized by a broad geographical coverage and a fast-track peer-review process, relevant topics include all aspects of biophysics, medical physics and biomedical engineering. Papers that are almost entirely clinical or biological in their focus are not suitable. The journal has an emphasis on publishing interdisciplinary work and bringing research fields together, encompassing experimental, theoretical and computational work.
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