评估用于治疗囊性纤维化相关慢性鼻炎的抗生物膜制剂。

IF 7.2 2区医学 Q1 OTORHINOLARYNGOLOGY International Forum of Allergy & Rhinology Pub Date : 2024-08-30 DOI:10.1002/alr.23441

Saartje Uyttebroek MD, Lieven Dupont MD, PhD, Jeroen Wagemans PhD, Rob Lavigne PhD, Maya Merabishvili PhD, Tom Coenye PhD, Laura Van Gerven MD, PhD

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摘要

要点：治疗囊性纤维化相关慢性鼻炎应针对鼻窦生物膜。含/不含木糖醇的 NaHCO3 盐具有有限的抗生物膜特性，而 rhDNAse 则没有。噬菌体的效果各不相同，取决于噬菌体和与抗生素的组合。

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Evaluation of antibiofilm agents for treatment of cystic fibrosis-related chronic rhinosinusitis

Key points

Treatment of cystic fibrosis-related chronic rhinosinusitis should target sinonasal biofilms.
NaHCO₃ salts with/without xylitol have limited antibiofilm properties, whereas rhDNAse has not.
Phage effectivity varies and depends on the phage and the combination with antibiotics.

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来源期刊

International Forum of Allergy & Rhinology OTORHINOLARYNGOLOGY-

CiteScore

11.70

自引率

10.90%

发文量

185

审稿时长

6-12 weeks

期刊介绍： International Forum of Allergy & Rhinologyis a peer-reviewed scientific journal, and the Official Journal of the American Rhinologic Society and the American Academy of Otolaryngic Allergy. International Forum of Allergy Rhinology provides a forum for clinical researchers, basic scientists, clinicians, and others to publish original research and explore controversies in the medical and surgical treatment of patients with otolaryngic allergy, rhinologic, and skull base conditions. The application of current research to the management of otolaryngic allergy, rhinologic, and skull base diseases and the need for further investigation will be highlighted.