幼儿期父母的社会经济地位与中年前脑血管疾病的遗传风险集群 - 1966 年芬兰北部出生队列。

IF 6.3 2区 医学 Q1 CLINICAL NEUROLOGY International Journal of Stroke Pub Date : 2024-09-30 DOI:10.1177/17474930241282521
Veronika Hyytiäinen, Leena Ala-Mursula, Petteri Oura, Markus Paananen, Ville Karhunen, Harri Rusanen, Mirjam I Geerlings, Jouko Miettunen, Ina Rissanen
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引用次数: 0

摘要

背景和目的:脑血管疾病(CVD)的发病率在年轻成年人中呈上升趋势(方法:在 1966 年芬兰北部出生队列(Northern Finland Birth Cohort)的 12,058 名儿童中,我们对个体进行了从妊娠期到 54 岁的跟踪调查。我们使用了之前公布的早期家庭经济和社会地位群组,该群组基于对产前收集的大量变量进行的潜类分析。我们利用多基因风险评分(PRS)和随访期间的父母心血管疾病调查了遗传风险。我们利用 Cox 回归分析了五个不同群组、遗传风险和中年前各类心血管疾病的相应风险之间的关联。所有分析首先在整个样本中进行,然后按照心血管研究的建议按性别进行分层:结果:在 586 943 人年的随访期间,共发生了 512 起心血管疾病。在 SES 群组与心血管疾病之间没有发现明显的关联。较高的 PRS 与任何心血管疾病有关(HR 每增加 1 SD 为 1.15;95%CI 为 1.02-1.31),与缺血性心血管疾病有关(HR 为 1.21;1.05-1.40)。我们没有发现早期家庭社会经济地位与心血管疾病遗传风险的综合关联:结论:在芬兰人口中,遗传风险与中年心血管疾病风险有关。我们没有发现早期家庭经济状况与心血管疾病之间有明显的联系。出生在特定的社会经济地位群体并不会增加遗传风险的影响。
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Clusters of parental socioeconomic status in early childhood and inherited risk for cerebrovascular disease until mid-life-Northern Finland Birth Cohort 1966.

Background and aims: The incidence of cerebrovascular disease (CVD) is rising among young adults (< 55 years). The risk for CVD starts to form in early childhood and is comprised of genetic and environmental risk factors. The aim of this study is to investigate the relationship between early family socioeconomic status (SES), inherited risk, and CVD until midlife.

Methods: In the Northern Finland Birth Cohort 1966 of 12,058 children, individuals were followed from gestational period up to 54 years. We used previously published early family SES clusters, based on latent class analysis of a wide set of prenatally collected variables. We investigated inherited risk with polygenic risk score (PRS) and parental CVDs during follow-up. The associations of the five distinct clusters, inherited risk, and consequent risk for various types of CVDs until middle age were analyzed with Cox regression. All analyses were conducted first in the whole sample and then stratified by sex as is recommended in cardiovascular studies.

Results: During the follow-up of 586,943 person-years, 512 CVDs occurred. No clear association between SES clusters and CVD were found. Higher PRS associated with any CVD (hazard ratio (HR) per 1 SD increase: 1.15; 95% confidence interval (CI): 1.02-1.31), and ischemic CVD (HR: 1.21; 1.05-1.40). We found no combined associations of early family SES and inherited risk for CVD.

Conclusions: Inherited risk was associated with the risk for CVD in mid-life in Finnish population. We found no clear connection with early family SES and CVD. Being born to a specific SES group did not increase the effect of inherited risk.

Data access statement: NFBC1966 data are available from the University of Oulu, Infrastructure for Population Studies for researchers who meet the criteria for accessing confidential data. In the use of data, we follow the EU general data protection regulation (679/2016) and Finnish Data Protection Act. Permission to use the data can be applied for research purposes from https://www.oulu.fi/nfbc.

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来源期刊
International Journal of Stroke
International Journal of Stroke 医学-外周血管病
CiteScore
13.90
自引率
6.00%
发文量
132
审稿时长
6-12 weeks
期刊介绍: The International Journal of Stroke is a welcome addition to the international stroke journal landscape in that it concentrates on the clinical aspects of stroke with basic science contributions in areas of clinical interest. Reviews of current topics are broadly based to encompass not only recent advances of global interest but also those which may be more important in certain regions and the journal regularly features items of news interest from all parts of the world. To facilitate the international nature of the journal, our Associate Editors from Europe, Asia, North America and South America coordinate segments of the journal.
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