{"title":"Co(II)、Ni(II)、Cu(II) 和 Zn(II) 与新合成的 2-甲氧基 5-三氟甲基苯胺席夫碱配合物的合成、表征、DNA 相互作用研究和生物学评价。","authors":"M Swathi, Dasari Ayodhya, Shivaraj","doi":"10.1007/s10895-024-03888-2","DOIUrl":null,"url":null,"abstract":"<p><p>The biologically active and thermally stable bivalent Co(II), Ni(II), Cu(II), and Zn(II) complexes (C1, C2, C3, and C4) of novel Schiff base ligand [(5-trifluoromethyl-2-methoxyphenylamino)methyl)-4,6-diiodophenol (L)] have been synthesized. The structural analysis of these complexes have been carried out by elemental analysis, <sup>1</sup>H-NMR, FTIR, ESI mass, UV-visible, ESR, TGA techniques and magnetic measurements. The obtained results were confirmed as square planar geometry for Ni(II) and Cu(II) complexes, whereas octahedral geometry for Co(II) and Zn(II) complexes. The geometry optimized structures were developed by employing CHEM 3D software. The DNA binding interaction studies such as UV-vis absorption, viscosity, and fluorescence studies have been confirmed that the mode of binding of complexes with DNA is an intercalative binding. The DNA cleavage studies revealed that all the complexes are found to be potent to cleave the DNA into Form I & II. The in-vitro pathological studies of all the complexes against various microbial strains (Gram + and Gram -), revealed that Cu(II) complexes are more potent compared to other complexes and Schiff base. The anti diabetic activity studies revealed that the Cu(II) complex exhibited slightly higher activity than Co(II), Ni(II), and Zn(II) complexes. The results of antioxidant activity by DPPH method, suggested that the Cu(II) complex has higher activity and comparable with the standard compounds.</p>","PeriodicalId":15800,"journal":{"name":"Journal of Fluorescence","volume":null,"pages":null},"PeriodicalIF":2.6000,"publicationDate":"2024-08-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Synthesis, Characterization, Investigation of DNA Interactions and Biological Evaluation of Co(II), Ni(II), Cu(II) and Zn(II) Complexes with Newly Synthesized 2-methoxy 5-trifluoromethyl benzenamine Schiff Base.\",\"authors\":\"M Swathi, Dasari Ayodhya, Shivaraj\",\"doi\":\"10.1007/s10895-024-03888-2\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><p>The biologically active and thermally stable bivalent Co(II), Ni(II), Cu(II), and Zn(II) complexes (C1, C2, C3, and C4) of novel Schiff base ligand [(5-trifluoromethyl-2-methoxyphenylamino)methyl)-4,6-diiodophenol (L)] have been synthesized. The structural analysis of these complexes have been carried out by elemental analysis, <sup>1</sup>H-NMR, FTIR, ESI mass, UV-visible, ESR, TGA techniques and magnetic measurements. The obtained results were confirmed as square planar geometry for Ni(II) and Cu(II) complexes, whereas octahedral geometry for Co(II) and Zn(II) complexes. The geometry optimized structures were developed by employing CHEM 3D software. The DNA binding interaction studies such as UV-vis absorption, viscosity, and fluorescence studies have been confirmed that the mode of binding of complexes with DNA is an intercalative binding. The DNA cleavage studies revealed that all the complexes are found to be potent to cleave the DNA into Form I & II. The in-vitro pathological studies of all the complexes against various microbial strains (Gram + and Gram -), revealed that Cu(II) complexes are more potent compared to other complexes and Schiff base. The anti diabetic activity studies revealed that the Cu(II) complex exhibited slightly higher activity than Co(II), Ni(II), and Zn(II) complexes. The results of antioxidant activity by DPPH method, suggested that the Cu(II) complex has higher activity and comparable with the standard compounds.</p>\",\"PeriodicalId\":15800,\"journal\":{\"name\":\"Journal of Fluorescence\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":2.6000,\"publicationDate\":\"2024-08-31\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Journal of Fluorescence\",\"FirstCategoryId\":\"92\",\"ListUrlMain\":\"https://doi.org/10.1007/s10895-024-03888-2\",\"RegionNum\":4,\"RegionCategory\":\"化学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q2\",\"JCRName\":\"BIOCHEMICAL RESEARCH METHODS\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of Fluorescence","FirstCategoryId":"92","ListUrlMain":"https://doi.org/10.1007/s10895-024-03888-2","RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"BIOCHEMICAL RESEARCH METHODS","Score":null,"Total":0}
引用次数: 0
摘要
合成了新型希夫碱配体[(5-三氟甲基-2-甲氧基苯基氨基)甲基)-4,6-二碘苯酚 (L)]的具有生物活性和热稳定性的二价 Co(II)、Ni(II)、Cu(II) 和 Zn(II) 配合物(C1、C2、C3 和 C4)。通过元素分析、1H-NMR、FTIR、ESI 质量、紫外可见光、ESR、TGA 技术和磁性测量对这些配合物进行了结构分析。所得结果证实,Ni(II) 和 Cu(II) 复合物的几何形状为正方形,而 Co(II) 和 Zn(II) 复合物的几何形状为八面体。几何优化结构是利用 CHEM 3D 软件开发的。DNA 结合相互作用研究(如紫外可见吸收、粘度和荧光研究)证实,配合物与 DNA 的结合模式为插层结合。DNA 裂解研究表明,所有复合物都能有效地将 DNA 裂解为 I 型和 II 型。所有配合物对各种微生物菌株(革兰氏阳性和革兰氏阴性)的体外病理学研究表明,Cu(II) 配合物比其他配合物和希夫碱更有效。抗糖尿病活性研究表明,Cu(II) 复合物的活性略高于 Co(II)、Ni(II) 和 Zn(II) 复合物。DPPH 法的抗氧化活性结果表明,Cu(II) 复合物具有更高的活性,可与标准化合物相媲美。
Synthesis, Characterization, Investigation of DNA Interactions and Biological Evaluation of Co(II), Ni(II), Cu(II) and Zn(II) Complexes with Newly Synthesized 2-methoxy 5-trifluoromethyl benzenamine Schiff Base.
The biologically active and thermally stable bivalent Co(II), Ni(II), Cu(II), and Zn(II) complexes (C1, C2, C3, and C4) of novel Schiff base ligand [(5-trifluoromethyl-2-methoxyphenylamino)methyl)-4,6-diiodophenol (L)] have been synthesized. The structural analysis of these complexes have been carried out by elemental analysis, 1H-NMR, FTIR, ESI mass, UV-visible, ESR, TGA techniques and magnetic measurements. The obtained results were confirmed as square planar geometry for Ni(II) and Cu(II) complexes, whereas octahedral geometry for Co(II) and Zn(II) complexes. The geometry optimized structures were developed by employing CHEM 3D software. The DNA binding interaction studies such as UV-vis absorption, viscosity, and fluorescence studies have been confirmed that the mode of binding of complexes with DNA is an intercalative binding. The DNA cleavage studies revealed that all the complexes are found to be potent to cleave the DNA into Form I & II. The in-vitro pathological studies of all the complexes against various microbial strains (Gram + and Gram -), revealed that Cu(II) complexes are more potent compared to other complexes and Schiff base. The anti diabetic activity studies revealed that the Cu(II) complex exhibited slightly higher activity than Co(II), Ni(II), and Zn(II) complexes. The results of antioxidant activity by DPPH method, suggested that the Cu(II) complex has higher activity and comparable with the standard compounds.
期刊介绍:
Journal of Fluorescence is an international forum for the publication of peer-reviewed original articles that advance the practice of this established spectroscopic technique. Topics covered include advances in theory/and or data analysis, studies of the photophysics of aromatic molecules, solvent, and environmental effects, development of stationary or time-resolved measurements, advances in fluorescence microscopy, imaging, photobleaching/recovery measurements, and/or phosphorescence for studies of cell biology, chemical biology and the advanced uses of fluorescence in flow cytometry/analysis, immunology, high throughput screening/drug discovery, DNA sequencing/arrays, genomics and proteomics. Typical applications might include studies of macromolecular dynamics and conformation, intracellular chemistry, and gene expression. The journal also publishes papers that describe the synthesis and characterization of new fluorophores, particularly those displaying unique sensitivities and/or optical properties. In addition to original articles, the Journal also publishes reviews, rapid communications, short communications, letters to the editor, topical news articles, and technical and design notes.