探索运动与二甲双胍对尼日利亚糖尿病前期患者胰岛素抵抗的影响:随机对照试验

IF 0.8 Q3 MEDICINE, GENERAL & INTERNAL Nigerian Postgraduate Medical Journal Pub Date : 2024-07-01 Epub Date: 2024-09-02 DOI:10.4103/npmj.npmj_148_24
Umar Musa Tambuwal, Sabir Anas Ahmad, Umar Hayatu, Maiyaki Abubakar Sadiq, Jimoh Ahmed Kolawale, Sada Kabiru Bello, Abdullahi Faruk Umar
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引用次数: 0

摘要

背景:糖尿病前期是发展成 2 型糖尿病的重要风险因素,在尼日利亚很常见。有效的干预可以逆转糖尿病前期胰岛素抵抗的潜在发病机制。本研究旨在确定和比较适度运动和二甲双胍干预对糖尿病前期参与者胰岛素抵抗的影响:采用随机安慰剂对照设计,通过简单随机抽样选取了 54 名尼日利亚糖尿病前期患者。他们接受了二甲双胍、适量运动或安慰剂治疗,并进行了为期 12 周的随访。对干预前后的胰岛素抵抗进行评估,并对结果进行比较:49名糖尿病前期患者完成了研究。干预 12 周后,运动组和二甲双胍组的参与者的胰岛素抵抗都比安慰剂组明显降低。不过,运动组的胰岛素抵抗降低了 77.3%(稳态模型评估-胰岛素抵抗 [HOMA-IR]),胰岛素敏感性提高了 81.2%(定量胰岛素敏感性检查指数 [QUICKI])。相比之下,二甲双胍组的参与者胰岛素抵抗降低了 66.3%(HOMA-IR),胰岛素敏感性提高了 76.2%(QUICKI):结论:在患有糖尿病前期的尼日利亚人中,适量运动和二甲双胍在改善胰岛素抵抗方面的疗效明显高于安慰剂。不过,适度运动对胰岛素抵抗的改善作用要大于二甲双胍干预。这项研究的参与者需要接受更长时间的随访,以评估这些干预措施的长期效果。
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Exploring the Effect of Exercise versus Metformin on Insulin Resistance amongst Nigerians with Pre-diabetes: A Randomised Controlled Trial.

Background: Pre-diabetes is an important risk factor for the development of type 2 diabetes and is common in Nigeria. Effective intervention can reverse the underlying pathogenesis of insulin resistance in pre-diabetes. This study aimed to determine and compare the impact of moderate exercise and metformin interventions on insulin resistance among participants with pre-diabetes.

Materials and methods: Using a randomised placebo-controlled design, 54 Nigerians with pre-diabetes were selected using simple random sampling. They were offered metformin, moderate exercise or placebo treatment and followed up for 12 weeks. Insulin resistance was assessed before and after the interventions and the outcome was compared.

Results: Forty-nine participants with pre-diabetes completed the study. Participants in both the exercise and metformin groups had significantly decreased insulin resistance compared to placebo after 12 weeks of intervention. However, there was a decrease in insulin resistance by 77.3% (homeostasis model assessment-insulin resistance [HOMA-IR]) and an increase in insulin sensitivity by 81.2% (quantitative insulin sensitivity check index [QUICKI]) in the exercise group. In comparison, participants in the metformin group had a decrease in insulin resistance by 66.3% (HOMA-IR) and an increase in insulin sensitivity by 76.2% (QUICKI).

Conclusion: Amongst Nigerians with pre-diabetes, both moderate exercise and metformin have significantly higher efficacy than placebo in improving insulin resistance. However, moderate exercise improved insulin resistance more than the metformin intervention. Participants in this study need to be followed up for a longer period to assess the long-term effects of these interventions.

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来源期刊
Nigerian Postgraduate Medical Journal
Nigerian Postgraduate Medical Journal MEDICINE, GENERAL & INTERNAL-
CiteScore
1.90
自引率
0.00%
发文量
52
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