欧拉诺芬通过 PI3K/AKT 通路抑制犬乳腺肿瘤细胞的生长并诱导其凋亡

IF 2.3 2区 农林科学 Q1 VETERINARY SCIENCES Veterinary and comparative oncology Pub Date : 2024-12-01 Epub Date: 2024-09-02 DOI:10.1111/vco.13005
Zhaoyan Lin, Rong Chen, Jiao Wang, Yu Zheng, Zixuan He, Ye Yan, Linxi Zhang, Xiaohong Huang, Hong Zhang
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引用次数: 0

摘要

犬乳腺肿瘤(CMT)是完整雌性犬最常见的自发性肿瘤,通常会发生转移。Auranofin (AF) 是一种金复合物,用于治疗风湿病。AF 的卓越抗肿瘤能力已在各种类型的人类和犬类肿瘤中得到证实。本研究使用了五种 CMT 细胞系(CIPp、CMT-7364、CHMp、CIPm 和 CTBp)和三种 CMT 原代细胞(G7894、L1883 和 L6783)来探讨 AF 对 CMT 的抗肿瘤作用。研究还使用了两种 CMT 细胞系(CIPp 和 CMT-7364)来探究 AF 对 CMT 影响的内在机制。结果表明,AF能抑制CMT细胞的生长、迁移、侵袭和集落形成能力。此外,AF 还能有效抑制 CMT 在三维细胞培养模型中的生长。此外,AF 还能通过 PI3K/AKT 通路诱导 CMT 细胞凋亡。总之,AF能通过调节PI3K/AKT通路有效诱导CMT细胞凋亡,这表明在未来的研究中应将AF作为一种潜在的CMT治疗方法进行探索。
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Auranofin Suppresses the Growth of Canine Mammary Tumour Cells and Induces Apoptosis via the PI3K/AKT Pathway.

Canine mammary gland tumour (CMT) is the most common spontaneous tumour in intact female dogs and often exhibits metastases. Auranofin (AF) is a gold complex used for treating rheumatism. The excellent anti-tumour ability of AF has been demonstrated in various types of human and canine tumours. In this study, five CMT cell lines (CIPp, CMT-7364, CHMp, CIPm and CTBp) and three CMT primary cells (G7894, L1883 and L6783) were used to explore the anti-tumour effect of AF on CMT. Two CMT cell lines (CIPp and CMT-7364) were used to search the underlying mechanism of the effect of AF on CMT. The results showed that AF inhibited the growth, migration, invasion, and colony formation abilities of CMT cells. Additionally, the growth of CMT in a 3D cell culture model was effectively suppressed by AF. Furthermore, AF induced cell apoptosis of CMT cells via the PI3K/AKT pathway. In conclusion, AF effectively induces CMT apoptosis by regulating the PI3K/AKT pathway, indicating that AF should be explored as a potential CMT treatment in future studies.

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来源期刊
Veterinary and comparative oncology
Veterinary and comparative oncology 农林科学-兽医学
CiteScore
4.80
自引率
9.50%
发文量
75
审稿时长
>24 weeks
期刊介绍: Veterinary and Comparative Oncology (VCO) is an international, peer-reviewed journal integrating clinical and scientific information from a variety of related disciplines and from worldwide sources for all veterinary oncologists and cancer researchers concerned with aetiology, diagnosis and clinical course of cancer in domestic animals and its prevention. With the ultimate aim of diminishing suffering from cancer, the journal supports the transfer of knowledge in all aspects of veterinary oncology, from the application of new laboratory technology to cancer prevention, early detection, diagnosis and therapy. In addition to original articles, the journal publishes solicited editorials, review articles, commentary, correspondence and abstracts from the published literature. Accordingly, studies describing laboratory work performed exclusively in purpose-bred domestic animals (e.g. dogs, cats, horses) will not be considered.
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