液体活检中用于胰腺癌早期检测的多生物标记物面板--全面综述。

IF 11.4 1区 医学 Q1 ONCOLOGY Journal of Experimental & Clinical Cancer Research Pub Date : 2024-09-02 DOI:10.1186/s13046-024-03166-w
Kim-Lea Reese, Klaus Pantel, Daniel J Smit
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引用次数: 0

摘要

胰腺导管腺癌(PDAC)常常在晚期才被发现,这导致治疗方案有限,总生存率很低。迄今为止,还没有一种检测早期 PDAC 的可靠方法可用于靶向筛查。液体活检可通过微创方式收集体液(通常是外周血),然后分析循环肿瘤细胞或肿瘤相关分子(如核酸、蛋白质或代谢物),这可能有助于 PDAC 的早期诊断。单一的生物标记物可能缺乏灵敏度和/或特异性,无法可靠地检测出 PDAC,而将这些循环生物标记物组合成多标记物板,可提高基于血液检测诊断的灵敏度和特异性。在这篇叙述性综述中,我们概述了用于早期诊断 PDAC 的不同液体生物标记物,并讨论了多标记物组合的有效性。
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Multibiomarker panels in liquid biopsy for early detection of pancreatic cancer - a comprehensive review.

Pancreatic ductal adenocarcinoma (PDAC) is frequently detected in late stages, which leads to limited therapeutic options and a dismal overall survival rate. To date, no robust method for the detection of early-stage PDAC that can be used for targeted screening approaches is available. Liquid biopsy allows the minimally invasive collection of body fluids (typically peripheral blood) and the subsequent analysis of circulating tumor cells or tumor-associated molecules such as nucleic acids, proteins, or metabolites that may be useful for the early diagnosis of PDAC. Single biomarkers may lack sensitivity and/or specificity to reliably detect PDAC, while combinations of these circulating biomarkers in multimarker panels may improve the sensitivity and specificity of blood test-based diagnosis. In this narrative review, we present an overview of different liquid biopsy biomarkers for the early diagnosis of PDAC and discuss the validity of multimarker panels.

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来源期刊
CiteScore
18.20
自引率
1.80%
发文量
333
审稿时长
1 months
期刊介绍: The Journal of Experimental & Clinical Cancer Research is an esteemed peer-reviewed publication that focuses on cancer research, encompassing everything from fundamental discoveries to practical applications. We welcome submissions that showcase groundbreaking advancements in the field of cancer research, especially those that bridge the gap between laboratory findings and clinical implementation. Our goal is to foster a deeper understanding of cancer, improve prevention and detection strategies, facilitate accurate diagnosis, and enhance treatment options. We are particularly interested in manuscripts that shed light on the mechanisms behind the development and progression of cancer, including metastasis. Additionally, we encourage submissions that explore molecular alterations or biomarkers that can help predict the efficacy of different treatments or identify drug resistance. Translational research related to targeted therapies, personalized medicine, tumor immunotherapy, and innovative approaches applicable to clinical investigations are also of great interest to us. We provide a platform for the dissemination of large-scale molecular characterizations of human tumors and encourage researchers to share their insights, discoveries, and methodologies with the wider scientific community. By publishing high-quality research articles, reviews, and commentaries, the Journal of Experimental & Clinical Cancer Research strives to contribute to the continuous improvement of cancer care and make a meaningful impact on patients' lives.
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