肺癌筛查:早期发现降低死亡率。

Delaware journal of public health Pub Date : 2024-08-28 eCollection Date: 2024-08-01 DOI:10.32481/djph.2024.08.07
Brian Nam, Danny Hamm, Nora Katurakes, Charles Mulligan
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引用次数: 0

摘要

肺癌仍然是美国癌症相关死亡率最高的疾病。虽然它是第三大确诊癌症,但发现时往往已是晚期。I 期肺癌的存活率超过 70%,而 IV 期肺癌的五年存活率不到 10%。多年来,人们一直在研究如何在早期发现肺癌,以便更有效地治疗。这些方法包括定期胸部 X 光检查(CXR)和痰液样本。遗憾的是,这些检测方式并未显示出任何益处。2011 年,全国肺筛查试验的数据公布后,情况发生了改变。这项具有里程碑意义的试验最终表明,每年对有严重吸烟史的患者进行一次低辐射剂量胸部计算机断层扫描(LDCT)可将肺癌相关死亡率降低 20%。这些结果推动了全国范围内加强肺癌筛查的努力。虽然在全国范围内接受筛查的符合条件的患者人数仍然不多,但各州和地方正在做出巨大努力,以提高人们的认识并改进筛查工作。这些努力还以服务不足的地区为目标,重点是减少获得筛查机会方面的差距。
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Lung Cancer Screening: Early Detection Decreases Mortality.

Lung cancer remains the number one cancer related mortality in the United States . While it is the third most diagnosed cancer, it is often found at an advanced stage. Survival rates for stage I lung cancer are above 70% while survival rates for stage IV lung cancer are less than 10% at five years. Methods to detect lung cancer at an earlier stage when it can be more effectively treated have been investigated for many years. These included regular chest x-rays (CXRs) and sputum samples. Unfortunately, these testing modalities did not show any benefit. This changed in 2011 when data from the National Lung Screening Trial were published. This landmark trial showed conclusively that a low-radiation dose chest computed tomography scan (LDCT) performed annually in patients with a heavy smoking history reduced lung cancer related mortality by 20%. These results have led to a nationwide effort to increase lung cancer screening. While the number of eligible patients that are being screened on a national level remains modest, significant efforts are being made at the state and local levels to increase awareness and to improve screening. These efforts have also targeted underserved areas and are focused on reducing disparities in access.

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