{"title":"工程人体心脏组织揭示了自身抗体在系统性红斑狼疮中的致病性。","authors":"Madeleine W. Cunningham","doi":"10.1038/s44161-024-00535-8","DOIUrl":null,"url":null,"abstract":"IgG autoantibodies from patients with systemic lupus erythematosus (SLE) and systolic dysfunction directly affect engineered human heart tissue, altering cellular composition, respiration and calcium handling. Four pathogenic autoantibodies that may target cardiomyocyte function provide insights into myocardial injury in SLE.","PeriodicalId":74245,"journal":{"name":"Nature cardiovascular research","volume":"3 9","pages":"1028-1030"},"PeriodicalIF":9.4000,"publicationDate":"2024-08-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Engineered human heart tissue reveals pathogenicity of autoantibodies in systemic lupus erythematosus\",\"authors\":\"Madeleine W. Cunningham\",\"doi\":\"10.1038/s44161-024-00535-8\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"IgG autoantibodies from patients with systemic lupus erythematosus (SLE) and systolic dysfunction directly affect engineered human heart tissue, altering cellular composition, respiration and calcium handling. Four pathogenic autoantibodies that may target cardiomyocyte function provide insights into myocardial injury in SLE.\",\"PeriodicalId\":74245,\"journal\":{\"name\":\"Nature cardiovascular research\",\"volume\":\"3 9\",\"pages\":\"1028-1030\"},\"PeriodicalIF\":9.4000,\"publicationDate\":\"2024-08-29\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Nature cardiovascular research\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://www.nature.com/articles/s44161-024-00535-8\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q1\",\"JCRName\":\"CARDIAC & CARDIOVASCULAR SYSTEMS\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Nature cardiovascular research","FirstCategoryId":"1085","ListUrlMain":"https://www.nature.com/articles/s44161-024-00535-8","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"CARDIAC & CARDIOVASCULAR SYSTEMS","Score":null,"Total":0}
Engineered human heart tissue reveals pathogenicity of autoantibodies in systemic lupus erythematosus
IgG autoantibodies from patients with systemic lupus erythematosus (SLE) and systolic dysfunction directly affect engineered human heart tissue, altering cellular composition, respiration and calcium handling. Four pathogenic autoantibodies that may target cardiomyocyte function provide insights into myocardial injury in SLE.
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