细胞外基质的组装和重塑机制

IF 81.3 1区 生物学 Q1 CELL BIOLOGY Nature Reviews Molecular Cell Biology Pub Date : 2024-09-02 DOI:10.1038/s41580-024-00767-3
Alexandra Naba
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引用次数: 0

摘要

细胞外基质(ECM)是由蛋白质和聚糖组成的复杂网状结构,是包围和支持细胞的支架。从赋予组织和器官物理和机械特性,到调节增殖、分化和迁移等细胞过程,细胞外基质在元动物生理学的各个方面都发挥着关键作用。因此,了解 ECM 支架的组装机制对于理解 ECM 在健康和疾病中的功能至关重要。本综述讨论了对基质组成分组成多样性的新见解,以及导致组织特异性组装和架构以支持特定功能的机制。然后,综述重点介绍了最近发现的机制,包括翻译后修饰和代谢途径,如氨基酸供应和昼夜节律,这些机制可调节 ECM 在体内平衡和人类疾病中的分泌、组装和重塑。最后,该综述探讨了 "母体疗法 "的潜力,即使 ECM 组成和结构正常化以达到治疗效果的策略。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

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Mechanisms of assembly and remodelling of the extracellular matrix
The extracellular matrix (ECM) is the complex meshwork of proteins and glycans that forms the scaffold that surrounds and supports cells. It exerts key roles in all aspects of metazoan physiology, from conferring physical and mechanical properties on tissues and organs to modulating cellular processes such as proliferation, differentiation and migration. Understanding the mechanisms that orchestrate the assembly of the ECM scaffold is thus crucial to understand ECM functions in health and disease. This Review discusses novel insights into the compositional diversity of matrisome components and the mechanisms that lead to tissue-specific assemblies and architectures tailored to support specific functions. The Review then highlights recently discovered mechanisms, including post-translational modifications and metabolic pathways such as amino acid availability and the circadian clock, that modulate ECM secretion, assembly and remodelling in homeostasis and human diseases. Last, the Review explores the potential of ‘matritherapies’, that is, strategies to normalize ECM composition and architecture to achieve a therapeutic benefit. The extracellular matrix (ECM) is a scaffold that supports cell structure and function. This Review discusses the compositional diversity, tissue-specific assembly and remodelling of the ECM in health and disease, and explores its potential for therapeutic targeting.
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来源期刊
Nature Reviews Molecular Cell Biology
Nature Reviews Molecular Cell Biology 生物-细胞生物学
CiteScore
173.60
自引率
0.50%
发文量
118
审稿时长
6-12 weeks
期刊介绍: Nature Reviews Molecular Cell Biology is a prestigious journal that aims to be the primary source of reviews and commentaries for the scientific communities it serves. The journal strives to publish articles that are authoritative, accessible, and enriched with easily understandable figures, tables, and other display items. The goal is to provide an unparalleled service to authors, referees, and readers, and the journal works diligently to maximize the usefulness and impact of each article. Nature Reviews Molecular Cell Biology publishes a variety of article types, including Reviews, Perspectives, Comments, and Research Highlights, all of which are relevant to molecular and cell biologists. The journal's broad scope ensures that the articles it publishes reach the widest possible audience.
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