SorC 家族细菌转录调节器的结构和功能。

IF 3.6 Q2 BIOCHEMISTRY & MOLECULAR BIOLOGY Transcription-Austin Pub Date : 2024-09-03 DOI:10.1080/21541264.2024.2387895
Markéta Šoltysová, Pavlína Řezáčová
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引用次数: 0

摘要

SorC 家族是一大类细菌转录调节因子,参与控制碳水化合物分解代谢和法定人数感应。SorC 蛋白由一个保守的 C 端效应结合域和一个 N 端 DNA 结合域组成,其类型将该家族分为两个亚家族:SorC/DeoR 和 SorC/CggR。众所周知,SorC/CggR 亚家族的蛋白质能调节糖酵解的关键节点--磷酸三糖的相互转化。另一方面,SorC/DeoR 蛋白参与各种外围碳水化合物分解途径和法定人数感应功能,包括毒力。尽管SorC蛋白家族的数量众多且十分重要,但它似乎仍处于科学兴趣的边缘,这可能是由于有关其代表蛋白的信息较为零散造成的。本综述旨在梳理现有的知识,并提供材料以启发未来有关 SorC 蛋白家族的问题。
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Structure and function of bacterial transcription regulators of the SorC family.

The SorC family is a large group of bacterial transcription regulators involved in controlling carbohydrate catabolism and quorum sensing. SorC proteins consist of a conserved C-terminal effector-binding domain and an N-terminal DNA-binding domain, whose type divides the family into two subfamilies: SorC/DeoR and SorC/CggR. Proteins of the SorC/CggR subfamily are known to regulate the key node of glycolysis-triose phosphate interconversion. On the other hand, SorC/DeoR proteins are involved in a variety of peripheral carbohydrate catabolic pathways and quorum sensing functions, including virulence. Despite the abundance and importance of this family, SorC proteins seem to be on the periphery of scientific interest, which might be caused by the fragmentary information about its representatives. This review aims to compile the existing knowledge and provide material to inspire future questions about the SorC protein family.

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来源期刊
Transcription-Austin
Transcription-Austin BIOCHEMISTRY & MOLECULAR BIOLOGY-
CiteScore
6.50
自引率
5.60%
发文量
9
期刊最新文献
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