糖尿病心血管并发症中免疫紊乱的研究轨迹及未来趋势调查：基于大数据的过去十年文献计量分析。

IF 12.5 1区医学 Q1 CELL BIOLOGY Ageing Research Reviews Pub Date : 2024-08-31 DOI:10.1016/j.arr.2024.102473

Xinglei Li , Zhou Xu , Tieqiu Huang , Yixin Jiang , Huan Wan , Deju Zhang , Jitao Ling , Yuting Wu , Xiao Liu , Pingping Yang , Linhua Fu , Jianping Liu , Jing Zhang , Peng Yu

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引用次数: 0

摘要

引言糖尿病心血管并发症是导致糖尿病患者死亡的首要原因，通常涉及免疫系统问题。尽管开展了大量研究，但仍缺乏广泛的数据来推动这一领域的发展。本研究旨在利用文献计量学方法系统分析免疫失调在这些并发症中的作用，勾勒出研究路径并预测未来方向：方法：分析了发表于 2014 年 1 月 1 日至 2023 年 12 月 31 日的 2,826 条来自 Web of Science Core Collection 的记录。使用 Microsoft Office Excel 2019、VOSviewer、CiteSpace 和 R 软件对合作网络、关键词共现、参考文献和研究热点进行了可视化分析：从2014年到2023年，有关该主题的研究论文和引用次数一直在增加，其中美国和中国的贡献很大。研究集中于氧化应激、炎症、新陈代谢、肠道微生物群和COVID-19对糖尿病心脏问题的影响，突出了免疫失调在这些疾病中的作用：这项研究概述了免疫失调在糖尿病心血管并发症中的作用，探讨了包括免疫调节、胰岛素抵抗和维生素 D 对心血管疾病的益处在内的潜在治疗方法，有助于推动该领域的发展。

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Investigating the research trajectory and future trends of immune disorders in diabetes cardiovascular complications: A bibliometric analysis over the past decade based on big data

Introduction

Cardiovascular complications of diabetes are a top cause of death in diabetics and often involve immune system problems. Despite numerous studies, there's a shortage of extensive data to advance this field. This study aims to systematically analyze the role of immune dysregulation in these complications using bibliometric methods, to outline the research path and predict future directions.

Methods

Published from January 1, 2014 to December 31, 2023, 2826 records from the Web of Science Core Collection were analyzed. Collaboration networks, keyword co-occurrences, references, and research hotspots were visualized and analyzed using Microsoft Office Excel 2019, VOSviewer, CiteSpace, and R software.

Results

The number of research papers and citations on this topic has been increasing from 2014 to 2023, with significant contributions from the United States and China. Studies have focused on the effects of oxidative stress, inflammation, metabolism, gut microbiota, and COVID-19 on diabetic heart problems, highlighting the role of immune dysregulation in these diseases.

Conclusion

This research provides an overview of immune dysregulation in the cardiovascular complications of diabetes, explores potential treatments including immunomodulation, insulin resistance, and the benefits of vitamin D on cardiovascular disease, and helps advance the field.

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来源期刊

Ageing Research Reviews 医学-老年医学

CiteScore

19.80

自引率

2.30%

发文量

216

审稿时长

55 days

期刊介绍： With the rise in average human life expectancy, the impact of ageing and age-related diseases on our society has become increasingly significant. Ageing research is now a focal point for numerous laboratories, encompassing leaders in genetics, molecular and cellular biology, biochemistry, and behavior. Ageing Research Reviews (ARR) serves as a cornerstone in this field, addressing emerging trends. ARR aims to fill a substantial gap by providing critical reviews and viewpoints on evolving discoveries concerning the mechanisms of ageing and age-related diseases. The rapid progress in understanding the mechanisms controlling cellular proliferation, differentiation, and survival is unveiling new insights into the regulation of ageing. From telomerase to stem cells, and from energy to oxyradical metabolism, we are witnessing an exciting era in the multidisciplinary field of ageing research. The journal explores the cellular and molecular foundations of interventions that extend lifespan, such as caloric restriction. It identifies the underpinnings of manipulations that extend lifespan, shedding light on novel approaches for preventing age-related diseases. ARR publishes articles on focused topics selected from the expansive field of ageing research, with a particular emphasis on the cellular and molecular mechanisms of the aging process. This includes age-related diseases like cancer, cardiovascular disease, diabetes, and neurodegenerative disorders. The journal also covers applications of basic ageing research to lifespan extension and disease prevention, offering a comprehensive platform for advancing our understanding of this critical field.