推进乳腺癌的三维诊断:X 射线相位对比显微层析技术在虚拟组织学中的变革力量

IF 11.8 1区 化学 Q1 CHEMISTRY, ANALYTICAL Trends in Analytical Chemistry Pub Date : 2024-08-29 DOI:10.1016/j.trac.2024.117943
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引用次数: 0

摘要

乳腺癌是全球女性的常见恶性肿瘤,需要准确检测组织变化,以进行有效诊断和治疗。组织学作为诊断的关键,面临着时间、有限的组织和缺乏全面的三维视图等挑战。本综述探讨了 X 射线显微层析虚拟组织学,作为解决组织学局限性的补充工具。特别是,相位对比技术提供了非破坏性、高分辨率的三维成像,超越了传统组织学的限制。相位对比显微层析成像技术为了解乳腺组织的变化提供了宝贵的信息,有助于早期癌症检测和提高诊断精度。本综述讨论了同步加速器设施的作用以及临床环境下的替代验证方法。本综述涉及的另一个重要方面是全球病理学家的短缺,这对及时准确地诊断乳腺癌构成了重大挑战。相位对比显微层析技术可为病理学家提供数字成像功能,从而实现远程会诊并减少对物理组织切片的依赖。
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Advancing breast cancer diagnosis in 3D: The transformative power of X-ray phase-contrast microtomography for virtual histology

Breast cancer, a prevalent global malignancy in women, demands accurate tissue alteration detection for effective diagnosis and treatment. Histology, pivotal in diagnosis, faces challenges like time, limited tissue, and lacking comprehensive three-dimensional views. This review explores X-ray microtomography virtual histology as a complementary tool to address histology's limitations. Particularly, phase-contrast techniques offer non-destructive, high-resolution 3D imaging, surpassing traditional histology constraints. Phase-contrast microtomography provides valuable insights into breast tissue alterations, aiding early cancer detection and enhancing diagnostic precision. The role of synchrotron facilities and alternative validation approaches for clinical settings are discussed. Another significant aspect covered in this review is the global shortage of pathologists, which poses a major challenge in the timely and accurate diagnosis of breast cancer. Phase-contrast microtomography can support pathologists by offering digital imaging capabilities, which enable remote consultation and reduce the dependency on physical tissue sections.

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来源期刊
Trends in Analytical Chemistry
Trends in Analytical Chemistry 化学-分析化学
CiteScore
20.00
自引率
4.60%
发文量
257
审稿时长
3.4 months
期刊介绍: TrAC publishes succinct and critical overviews of recent advancements in analytical chemistry, designed to assist analytical chemists and other users of analytical techniques. These reviews offer excellent, up-to-date, and timely coverage of various topics within analytical chemistry. Encompassing areas such as analytical instrumentation, biomedical analysis, biomolecular analysis, biosensors, chemical analysis, chemometrics, clinical chemistry, drug discovery, environmental analysis and monitoring, food analysis, forensic science, laboratory automation, materials science, metabolomics, pesticide-residue analysis, pharmaceutical analysis, proteomics, surface science, and water analysis and monitoring, these critical reviews provide comprehensive insights for practitioners in the field.
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