通过分子可视化教授蛋白质结构和功能。

IF 1.2 4区 教育学 Q4 BIOCHEMISTRY & MOLECULAR BIOLOGY Biochemistry and Molecular Biology Education Pub Date : 2024-09-04 DOI:10.1002/bmb.21860
Elisabeth Baland, Lucía Pérez Jimenez, André Mateus
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引用次数: 0

摘要

蛋白质的功能由其三维结构决定。这种结构由氨基酸的化学特性和原子相互作用决定。学习生物化学(尤其是蛋白质化学)的学生可以通过观察蛋白质结构,了解蛋白质是如何构建和折叠的。由于蛋白质的三维性质,教科书中静态的二维表述可能会限制学生的学习。在此,我们开发了一系列教程,向学生介绍分子图形软件。学生们面临的挑战是如何应用软件来观察蛋白质,并深入理解氨基酸的性质与结构之间的联系。我们还让学生熟悉计算结构生物学的一些最新工具。学生们以可视化的热情完成了教程,并对能够可视化讲课过程中学到的理论概念普遍表示满意。我们为学生留出了自我探索的空间,进一步激发了学生的参与热情。我们分享了教程说明,供其他教师借鉴,并根据学生的反馈提出了进一步改进的建议。总之,我们介绍了一系列针对蛋白质生物化学高级课程学生的教程,使他们能够探索蛋白质结构的宇宙以及这些结构与功能的关系。
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Teaching protein structure and function through molecular visualization.

The function of proteins is governed by their three-dimensional structure. This structure is determined by the chemical characteristics and atomic interactions of amino acids. Students of biochemistry, with a particular focus on protein chemistry, benefit from looking at protein structures and understanding how proteins are built and fold. Due to their three-dimensional nature, static two-dimensional representations in textbooks can be limiting to student learning. Here, we developed a series of tutorials that introduce students to molecular graphics software. The students are challenged to apply the software to look at proteins and to get a deeper understanding of how amino acid properties are linked to structure. We also familiarize students with some of the latest tools in computational structural biology. Students performed the tutorials with visual enthusiasm and reported general satisfaction in being able to visualize theoretical concepts learned during lectures. We further stimulated student engagement by allowing space for self-exploration. We share the tutorial instructions for other teachers to build on them, and we also offer suggestions for further improvement based on student feedback. In summary, we present a series of tutorials aimed at students of an advanced course in protein biochemistry to enable them to explore the universe of protein structures and how those relate to function.

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来源期刊
Biochemistry and Molecular Biology Education
Biochemistry and Molecular Biology Education 生物-生化与分子生物学
CiteScore
2.60
自引率
14.30%
发文量
99
审稿时长
6-12 weeks
期刊介绍: The aim of BAMBED is to enhance teacher preparation and student learning in Biochemistry, Molecular Biology, and related sciences such as Biophysics and Cell Biology, by promoting the world-wide dissemination of educational materials. BAMBED seeks and communicates articles on many topics, including: Innovative techniques in teaching and learning. New pedagogical approaches. Research in biochemistry and molecular biology education. Reviews on emerging areas of Biochemistry and Molecular Biology to provide background for the preparation of lectures, seminars, student presentations, dissertations, etc. Historical Reviews describing "Paths to Discovery". Novel and proven laboratory experiments that have both skill-building and discovery-based characteristics. Reviews of relevant textbooks, software, and websites. Descriptions of software for educational use. Descriptions of multimedia materials such as tutorials on various aspects of biochemistry and molecular biology.
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