淀粉样蛋白负荷对任务难度的 BOLD 调制的年龄差异。

IF 2.9 2区 医学 Q2 NEUROSCIENCES Cerebral cortex Pub Date : 2024-09-03 DOI:10.1093/cercor/bhae357
Joseph P Hennessee, Tzu-Chen Lung, Denise C Park, Kristen M Kennedy
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引用次数: 0

摘要

随着任务需求的增加,有效的认知表现往往需要分配额外的神经资源(即血氧水平依赖性[BOLD]激活),而这种与需求相关的调节受到淀粉样蛋白-β沉积和正常衰老的影响。本研究调查了淀粉样蛋白、调节和认知功能(即流体能力)之间的复杂关系。达拉斯终生脑研究(DLBS,n = 252,50-89 岁)的参与者在功能性磁共振成像(fMRI)中完成了一项语义判断任务,判断的分类难度各不相同。淀粉样蛋白负荷是通过使用 18F-florbetapir 的正电子发射断层扫描(PET)进行评估的。观察发现,淀粉样蛋白标准化摄取率(SUVRs)与BOLD调制之间存在二次关系,SUVRs中度升高者(如刚刚达到淀粉样蛋白阳性)的调制较弱,而SUVRs非常高者(如SUVR>1.5)则表现出较强的调制。更大的调节与更好的流体能力有关,这种关系在年轻参与者和淀粉样蛋白负荷较低者中最为明显。这些结果支持这样一种理论,即有效的需求相关调节有助于健康的认知老化,尤其是在从中年向老年过渡的过程中,而高调节在有大量淀粉样蛋白沉积的人群中可能会出现功能障碍。
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Age differences in BOLD modulation to task difficulty as a function of amyloid burden.

Effective cognitive performance often requires the allocation of additional neural resources (i.e. blood-oxygen-level-dependent [BOLD] activation) as task demands increase, and this demand-related modulation is affected by amyloid-beta deposition and normal aging. The present study investigated these complex relationships between amyloid, modulation, and cognitive function (i.e. fluid ability). Participants from the Dallas Lifespan Brain Study (DLBS, n = 252, ages 50-89) completed a semantic judgment task during functional magnetic resonance imaging (fMRI) where the judgments differed in classification difficulty. Amyloid burden was assessed via positron emission tomography (PET) using 18F-florbetapir. A quadratic relationship between amyloid standardized value uptake ratios (SUVRs) and BOLD modulation was observed such that modulation was weaker in those with moderately elevated SUVRs (e.g. just reaching amyloid-positivity), whereas those with very high SUVRs (e.g. SUVR > 1.5) showed strong modulation. Greater modulation was related to better fluid ability, and this relationship was strongest in younger participants and those with lower amyloid burden. These results support the theory that effective demand-related modulation contributes to healthy cognitive aging, especially in the transition from middle age to older adulthood, whereas high modulation may be dysfunctional in those with substantial amyloid deposition.

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来源期刊
Cerebral cortex
Cerebral cortex 医学-神经科学
CiteScore
6.30
自引率
8.10%
发文量
510
审稿时长
2 months
期刊介绍: Cerebral Cortex publishes papers on the development, organization, plasticity, and function of the cerebral cortex, including the hippocampus. Studies with clear relevance to the cerebral cortex, such as the thalamocortical relationship or cortico-subcortical interactions, are also included. The journal is multidisciplinary and covers the large variety of modern neurobiological and neuropsychological techniques, including anatomy, biochemistry, molecular neurobiology, electrophysiology, behavior, artificial intelligence, and theoretical modeling. In addition to research articles, special features such as brief reviews, book reviews, and commentaries are included.
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My science and career with Joseph E. LeDoux. Individual differences in functional connectivity during suppression of imagined threat. When emotion and time meet from human and rodent perspectives: a central role for the amygdala? Introspective psychophysics for the study of subjective experience. Examining threat responses through a developmental lens.
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