{"title":"大鼠模型中的静态负荷：评估和了解衰老的有效工具。","authors":"Dandan Chen, Xiaohong Deng, Yuxin Jia, Xianjun Sun, Xiaohong Duan, Shikai Yan, Jianhua Huang","doi":"10.1111/ggi.14950","DOIUrl":null,"url":null,"abstract":"<p><strong>Aim: </strong>Aging and age-related diseases are an ever-increasing social and public health problem. Allostatic load (AL) shows great potential as an interdisciplinary tool for assessing the aging of human beings but as yet lacks investigation in animal models which is our study focus at.</p><p><strong>Methods: </strong>Here a continuous study of AL was conducted on naturally aging rats. Blood samples were collected from the rats at ages of 5, 8, 14, 18, and 21 months. Dozens of blood biochemical indicators, including serum corticosterone, total cholesterol, low-density lipoprotein cholesterol, high-density lipoprotein cholesterol, triglycerides, C-reactive protein, interleukin-6, 25-hydroxyvitamin D, free fatty acid, CD3<sup>+</sup> T cell count, CD4<sup>+</sup>/CD3<sup>+</sup> T cell ratio, CD8<sup>+</sup>/CD3<sup>+</sup> T cell ratio, and CD3/4/8<sup>+</sup> T cell apoptosis, were determined.</p><p><strong>Results: </strong>AL was scored from those indicators, and we found that AL score gradually increased with age.</p><p><strong>Conclusions: </strong>AL can reliably reveal the cumulative and systemic changes in aging. Geriatr Gerontol Int 2024; ••: ••-••.</p>","PeriodicalId":12546,"journal":{"name":"Geriatrics & Gerontology International","volume":null,"pages":null},"PeriodicalIF":2.4000,"publicationDate":"2024-09-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Allostatic load in rat model: An efficient tool for evaluating and understanding aging.\",\"authors\":\"Dandan Chen, Xiaohong Deng, Yuxin Jia, Xianjun Sun, Xiaohong Duan, Shikai Yan, Jianhua Huang\",\"doi\":\"10.1111/ggi.14950\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Aim: </strong>Aging and age-related diseases are an ever-increasing social and public health problem. Allostatic load (AL) shows great potential as an interdisciplinary tool for assessing the aging of human beings but as yet lacks investigation in animal models which is our study focus at.</p><p><strong>Methods: </strong>Here a continuous study of AL was conducted on naturally aging rats. Blood samples were collected from the rats at ages of 5, 8, 14, 18, and 21 months. Dozens of blood biochemical indicators, including serum corticosterone, total cholesterol, low-density lipoprotein cholesterol, high-density lipoprotein cholesterol, triglycerides, C-reactive protein, interleukin-6, 25-hydroxyvitamin D, free fatty acid, CD3<sup>+</sup> T cell count, CD4<sup>+</sup>/CD3<sup>+</sup> T cell ratio, CD8<sup>+</sup>/CD3<sup>+</sup> T cell ratio, and CD3/4/8<sup>+</sup> T cell apoptosis, were determined.</p><p><strong>Results: </strong>AL was scored from those indicators, and we found that AL score gradually increased with age.</p><p><strong>Conclusions: </strong>AL can reliably reveal the cumulative and systemic changes in aging. Geriatr Gerontol Int 2024; ••: ••-••.</p>\",\"PeriodicalId\":12546,\"journal\":{\"name\":\"Geriatrics & Gerontology International\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":2.4000,\"publicationDate\":\"2024-09-03\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Geriatrics & Gerontology International\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.1111/ggi.14950\",\"RegionNum\":4,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q3\",\"JCRName\":\"GERIATRICS & GERONTOLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Geriatrics & Gerontology International","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1111/ggi.14950","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"GERIATRICS & GERONTOLOGY","Score":null,"Total":0}
Allostatic load in rat model: An efficient tool for evaluating and understanding aging.
Aim: Aging and age-related diseases are an ever-increasing social and public health problem. Allostatic load (AL) shows great potential as an interdisciplinary tool for assessing the aging of human beings but as yet lacks investigation in animal models which is our study focus at.
Methods: Here a continuous study of AL was conducted on naturally aging rats. Blood samples were collected from the rats at ages of 5, 8, 14, 18, and 21 months. Dozens of blood biochemical indicators, including serum corticosterone, total cholesterol, low-density lipoprotein cholesterol, high-density lipoprotein cholesterol, triglycerides, C-reactive protein, interleukin-6, 25-hydroxyvitamin D, free fatty acid, CD3+ T cell count, CD4+/CD3+ T cell ratio, CD8+/CD3+ T cell ratio, and CD3/4/8+ T cell apoptosis, were determined.
Results: AL was scored from those indicators, and we found that AL score gradually increased with age.
Conclusions: AL can reliably reveal the cumulative and systemic changes in aging. Geriatr Gerontol Int 2024; ••: ••-••.
期刊介绍：
Geriatrics & Gerontology International is the official Journal of the Japan Geriatrics Society, reflecting the growing importance of the subject area in developed economies and their particular significance to a country like Japan with a large aging population. Geriatrics & Gerontology International is now an international publication with contributions from around the world and published four times per year.
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